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GSTA1 glutathione S-transferase alpha 1 [ Homo sapiens (human) ]

Gene ID: 2938, updated on 7-Dec-2018

Summary

Official Symbol
GSTA1provided by HGNC
Official Full Name
glutathione S-transferase alpha 1provided by HGNC
Primary source
HGNC:HGNC:4626
See related
Ensembl:ENSG00000243955 MIM:138359
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GST2; GTH1; GSTA1-1; GST-epsilon
Summary
This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Biased expression in liver (RPKM 342.4), kidney (RPKM 288.3) and 6 other tissues See more
Orthologs

Genomic context

See GSTA1 in Genome Data Viewer
Location:
6p12.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (52791380..52803967, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52656178..52668664, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase alpha 2 Neighboring gene glutathione S-transferase alpha 12, pseudogene Neighboring gene glutathione S-transferase alpha 6, pseudogene Neighboring gene glutathione S-transferase alpha 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131939

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
glutathione transferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
linoleic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
glutathione S-transferase A1
Names
GST HA subunit 1
GST class-alpha member 1
S-(hydroxyalkyl)glutathione lyase A1
glutathione S-alkyltransferase A1
glutathione S-aryltransferase A1
glutathione S-transferase 2
glutathione S-transferase Ha subunit 1
testicular tissue protein Li 80
NP_001305988.1
NP_665683.1
XP_005249091.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319059.1NP_001305988.1  glutathione S-transferase A1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AL590363
    Conserved Domains (1) summary
    cd03208
    Location:1127
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
  2. NM_145740.5NP_665683.1  glutathione S-transferase A1 isoform 1

    See identical proteins and their annotated locations for NP_665683.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encode the longer isoform (1).
    Source sequence(s)
    AL590363, BC053578, BM973137, DC339498
    Consensus CDS
    CCDS4945.1
    UniProtKB/Swiss-Prot
    P08263
    UniProtKB/TrEMBL
    A0A140VJK4
    Related
    ENSP00000335620.5, ENST00000334575.5
    Conserved Domains (2) summary
    cd03208
    Location:86220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:482
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    52791380..52803967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249034.4XP_005249091.1  glutathione S-transferase A1 isoform X1

    See identical proteins and their annotated locations for XP_005249091.1

    UniProtKB/TrEMBL
    B7Z1F9
    Conserved Domains (2) summary
    cd03077
    Location:482
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    cl02776
    Location:86182
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
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