Bmp2 bone morphogenetic protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29373, updated on 30-Jul-2025

Summary

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Official Symbol: Bmp2provided by RGD
Official Full Name: bone morphogenetic protein 2provided by RGD
Primary source: RGD:2211
See related: Ensembl:ENSRNOG00000071010 AllianceGenome:RGD:2211
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables growth factor activity; identical protein binding activity; and protein domain specific binding activity. Involved in several processes, including BMP signaling pathway; cardiac muscle hypertrophy in response to stress; and cellular response to mechanical stimulus. Acts upstream of or within positive regulation of neurogenesis and positive regulation of transcription by RNA polymerase II. Located in extracellular space and vesicle. Part of protein-containing complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); hemochromatosis type 1; otosclerosis; short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1; and tooth agenesis. Orthologous to human BMP2 (bone morphogenetic protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Adrenal (RPKM 34.3), Liver (RPKM 23.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Bmp2 in Genome Data Viewer

Location:: 3q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (141264648..141275416)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (120812660..120822579)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (126335963..126346771)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-20 promotes cartilage repair in knee osteoarthritis rats via BMP2/Smad1 signaling pathway.
Title: MiR-20 promotes cartilage repair in knee osteoarthritis rats via BMP2/Smad1 signaling pathway.
H3K27me3-modulated Hofbauer cell BMP2 signalling enhancement compensates for shallow trophoblast invasion in preeclampsia.
Title: H3K27me3-modulated Hofbauer cell BMP2 signalling enhancement compensates for shallow trophoblast invasion in preeclampsia.
The impact of IGF-1 on alveolar bone remodeling and BMP-2 expression in orthodontic tooth movement in diabetic rats.
Title: The impact of IGF-1 on alveolar bone remodeling and BMP-2 expression in orthodontic tooth movement in diabetic rats.
Imbalance in Bone Morphogenic Proteins 2 and 7 Is Associated with Renal and Cardiovascular Damage in Chronic Kidney Disease.
Title: Imbalance in Bone Morphogenic Proteins 2 and 7 Is Associated with Renal and Cardiovascular Damage in Chronic Kidney Disease.
Sustained release of BMP-2 using self-assembled layer-by-layer film-coated implants enhances bone regeneration over burst release.
Title: Sustained release of BMP-2 using self-assembled layer-by-layer film-coated implants enhances bone regeneration over burst release.
Enhanced Bone Regeneration by Bone Morphogenetic Protein-2 after Pretreatment with Low-Intensity Pulsed Ultrasound in Distraction Osteogenesis.
Title: Enhanced Bone Regeneration by Bone Morphogenetic Protein-2 after Pretreatment with Low-Intensity Pulsed Ultrasound in Distraction Osteogenesis.
Bone morphogenetic proteins in biomineralization of two endodontic restorative cements.
Title: Bone morphogenetic proteins in biomineralization of two endodontic restorative cements.
Circular RNA circ_0000020 promotes osteogenic differentiation to reduce osteoporosis via sponging microRNA miR-142-5p to up-regulate Bone Morphogenetic Protein BMP2.
Title: Circular RNA circ_0000020 promotes osteogenic differentiation to reduce osteoporosis via sponging microRNA miR-142-5p to up-regulate Bone Morphogenetic Protein BMP2.
Changes in BMP-2 expression and mechanical properties during treatment of rats with osteoporotic hindlimb fracture with strontium ranelate.
Title: Changes in BMP-2 expression and mechanical properties during treatment of rats with osteoporotic hindlimb fracture with strontium ranelate.
HBO Promotes the Differentiation of Neural Stem Cells via Interactions Between the Wnt3/beta-Catenin and BMP2 Signaling Pathways.
Title: HBO Promotes the Differentiation of Neural Stem Cells via Interactions Between the Wnt3/β-Catenin and BMP2 Signaling Pathways.

Submit: New GeneRIF Correction See all GeneRIFs (108)

General gene information

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Markers

UniSTS:464654 (e-PCR)
- UniSTS:464654

Bmp2 (e-PCR), detects polymorphism
- UniSTS:464654

Bmp2 (e-PCR), detects polymorphism
- UniSTS:186499

RH131457 (e-PCR)
- UniSTS:214740

UniSTS:496639 (e-PCR)
- UniSTS:496639

Bmp2 (e-PCR), detects polymorphism
- UniSTS:496639

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BMP receptor binding	ISO Inferred from Sequence Orthology more info
enables co-receptor binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatase activator activity	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of ameloblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aortic valve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in atrioventricular canal morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within atrioventricular valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in bone development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac atrium formation	ISO Inferred from Sequence Orthology more info
involved_in cardiac epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in cardiac jelly development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy in response to stress	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle hypertrophy in response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in cardiocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cellular response to BMP stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within corticotropin hormone secreting cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic heart tube anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocardial cushion morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endodermal-mesodermal cell signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in heart induction	ISO Inferred from Sequence Orthology more info
involved_in heart morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
involved_in lung vasculature development	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesenchymal cell proliferation involved in ureteric bud development	ISO Inferred from Sequence Orthology more info
involved_in mesenchyme development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of aldosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium-independent cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cortisol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in ovulation cycle	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within pericardium development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization involved in bone maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cartilage development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extracellular matrix constituent secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organismal process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neurogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of odontoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of odontoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of odontogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ossification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peroxisome proliferator activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein destabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteoglycan metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of multicellular organismal development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within telencephalon development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within telencephalon regionalization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thyroid-stimulating hormone-secreting cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BMP receptor complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
part_of enzyme activator complex	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bone morphogenetic protein 2

Names: BMP-2; BMP-2A; bone morphogenetic protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017178.2 → NP_058874.2 bone morphogenetic protein 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P49001

UniProtKB/TrEMBL

A6HQI1, G3V8W4

Related

ENSRNOP00000081600.1, ENSRNOT00000108290.2

Conserved Domains (2) summary

cd19390
Location:292 → 394

TGF_beta_BMP2; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins

pfam00688
Location:41 → 265

TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

141264648..141275416

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104435.2 → XP_038960363.1 bone morphogenetic protein 2 isoform X1

UniProtKB/Swiss-Prot

P49001

Conserved Domains (2) summary

cd19390
Location:234 → 336

TGF_beta_BMP2; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins

pfam00688
Location:1 → 207

TGFb_propeptide; TGF-beta propeptide