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B3gat3 beta-1,3-glucuronyltransferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293722, updated on 5-Jul-2025
Official Symbol
B3gat3provided by RGD
Official Full Name
beta-1,3-glucuronyltransferase 3provided by RGD
Primary source
RGD:1311968
See related
Ensembl:ENSRNOG00000019873 AllianceGenome:RGD:1311968
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable glucuronosyltransferase activity and protein phosphatase activator activity. Predicted to be involved in glycosaminoglycan biosynthetic process; positive regulation of catalytic activity; and positive regulation of intracellular protein transport. Predicted to act upstream of or within chondroitin sulfate proteoglycan biosynthetic process; dermatan sulfate proteoglycan biosynthetic process; and heparan sulfate proteoglycan biosynthetic process. Predicted to be located in cis-Golgi network. Human ortholog(s) of this gene implicated in Larsen-like syndrome B3GAT3 type. Orthologous to human B3GAT3 (beta-1,3-glucuronyltransferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 367.5), Kidney (RPKM 180.8) and 9 other tissues See more
Orthologs
human mouse all
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See B3gat3 in Genome Data Viewer
Location:
1q43
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215246453..215253033)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205817374..205823928)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225120061..225126579)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551607 Neighboring gene integrator complex subunit 5 Neighboring gene glucosidase II alpha subunit Neighboring gene retinal outer segment membrane protein 1 Neighboring gene EMAP like 3

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia is caused by a novel mutation in B3GAT3. Budde BS, et al. Hum Genet, 2015 Jul. PMID 25893793
  2. Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: a strategy to promote cartilage repair. Venkatesan N, et al. Proc Natl Acad Sci U S A, 2004 Dec 28. PMID 15601778, Free PMC Article
  3. Faulty initiation of proteoglycan synthesis causes cardiac and joint defects. Baasanjav S, et al. Am J Hum Genet, 2011 Jul 15. PMID 21763480, Free PMC Article
  4. Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans. Koike T, et al. J Biol Chem, 2014 Mar 7. PMID 24425863, Free PMC Article
  5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GlcAT-I has a role in controlling and reversing articular cartilage defects
    Title: Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: a strategy to promote cartilage repair.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC188078
Preferred Names
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
Names
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
NP_001121656.1
XP_038964511.1
XP_063142988.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128184.1 → NP_001121656.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

    See identical proteins and their annotated locations for NP_001121656.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A0A8I6AFX5, B2GV35, B5DEK9
    Related
    ENSRNOP00000105268.1, ENSRNOT00000173965.1
    Conserved Domains (1) summary
    cd00218
    Location:75 → 313
    GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    215246453..215253033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108583.2 → XP_038964511.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 isoform X2

    Conserved Domains (1) summary
    cl11394
    Location:75 → 206
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  2. XM_063286918.1 → XP_063142988.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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