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Lrp5 LDL receptor related protein 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293649, updated on 12-Mar-2017
Official Symbol
Lrp5provided by RGD
Official Full Name
LDL receptor related protein 5provided by RGD
Primary source
RGD:1309329
See related
Ensembl:ENSRNOG00000015911
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Orthologs
Location:
1q42-q43
Exon count:
23
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (218816833..218920147, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (225689353..225793075, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6, regulatory subunit 3 Neighboring gene uncharacterized LOC103691272 Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene 40S ribosomal protein S9 pseudogene Neighboring gene similar to RIKEN cDNA 1810055G02 Neighboring gene family with sequence similarity 18, member B, pseudogene 1

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Breast cancer, organism-specific biosystem (from KEGG)
    Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Breast cancer, conserved biosystem (from KEGG)
    Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane, organism-specific biosystem (from REACTOME)
    Disassembly of the destruction complex and recruitment of AXIN to the membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
    TCF dependent signaling in response to WNT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

Markers

Homology

Clone Names

  • MGC188568

Gene Ontology Provided by RGD

Function Evidence Code Pubs
Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Wnt-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Wnt-protein binding ISO
Inferred from Sequence Orthology
more info
 
coreceptor activity involved in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
coreceptor activity involved in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
NOT toxin transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Wnt signaling pathway involved in dorsal/ventral axis specification IBA
Inferred from Biological aspect of Ancestor
more info
 
Wnt signaling pathway involved in dorsal/ventral axis specification ISO
Inferred from Sequence Orthology
more info
 
adipose tissue development IBA
Inferred from Biological aspect of Ancestor
more info
 
adipose tissue development ISO
Inferred from Sequence Orthology
more info
 
anatomical structure regression IEA
Inferred from Electronic Annotation
more info
 
anatomical structure regression ISO
Inferred from Sequence Orthology
more info
 
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
 
apoptotic process involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
bone development ISO
Inferred from Sequence Orthology
more info
 
bone marrow development IBA
Inferred from Biological aspect of Ancestor
more info
 
bone marrow development ISO
Inferred from Sequence Orthology
more info
 
bone morphogenesis IEA
Inferred from Electronic Annotation
more info
 
bone morphogenesis ISO
Inferred from Sequence Orthology
more info
 
bone remodeling IEA
Inferred from Electronic Annotation
more info
 
bone remodeling ISO
Inferred from Sequence Orthology
more info
 
branching involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in mammary gland duct morphogenesis ISO
Inferred from Sequence Orthology
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cell migration involved in gastrulation IEA
Inferred from Electronic Annotation
more info
 
cell migration involved in gastrulation ISO
Inferred from Sequence Orthology
more info
 
cell-cell signaling involved in mammary gland development IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling involved in mammary gland development ISO
Inferred from Sequence Orthology
more info
 
cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix-cell signaling IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix-cell signaling ISO
Inferred from Sequence Orthology
more info
 
gastrulation with mouth forming second IEA
Inferred from Electronic Annotation
more info
 
gastrulation with mouth forming second ISO
Inferred from Sequence Orthology
more info
 
glucose catabolic process IEA
Inferred from Electronic Annotation
more info
 
glucose catabolic process ISO
Inferred from Sequence Orthology
more info
 
limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
mammary gland duct morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
osteoblast development IBA
Inferred from Biological aspect of Ancestor
more info
 
osteoblast development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
NOT positive regulation of skeletal muscle acetylcholine-gated channel clustering ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of bone remodeling IEA
Inferred from Electronic Annotation
more info
 
regulation of bone remodeling ISO
Inferred from Sequence Orthology
more info
 
regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of insulin secretion involved in cellular response to glucose stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
retina morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
retina morphogenesis in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
retina vasculature morphogenesis in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
retinal blood vessel morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
retinal blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
vasculature development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
low-density lipoprotein receptor-related protein 5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106321.2NP_001099791.2  low-density lipoprotein receptor-related protein 5 precursor

    See identical proteins and their annotated locations for NP_001099791.2

    Status: PROVISIONAL

    Source sequence(s)
    BC166786
    UniProtKB/TrEMBL
    B2RYI1
    Related
    ENSRNOP00000022213, ENSRNOT00000022213
    Conserved Domains (6) summary
    smart00135
    Location:408450
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:13211355
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:720756
    NHL; NHL repeat [structural motif]
    pfam00058
    Location:163203
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:299336
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl18310
    Location:685878
    NHL; NHL repeat unit of beta-propeller proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    218816833..218920147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230726.3XP_006230788.1  low-density lipoprotein receptor-related protein 5 isoform X1

    Conserved Domains (6) summary
    smart00135
    Location:408450
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:12981332
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:720756
    NHL; NHL repeat [structural motif]
    pfam00058
    Location:163203
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:299336
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl18310
    Location:685878
    NHL; NHL repeat unit of beta-propeller proteins

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    198369819..198473093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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