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Ptdss2 phosphatidylserine synthase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293620, updated on 24-Jul-2025
Official Symbol
Ptdss2provided by RGD
Official Full Name
phosphatidylserine synthase 2provided by RGD
Primary source
RGD:1307914
See related
Ensembl:ENSRNOG00000015912 AllianceGenome:RGD:1307914
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PSS-2
Summary
Predicted to enable CDP-diacylglycerol-serine O-phosphatidyltransferase activity and L-serine-phosphatidylethanolamine phosphatidyltransferase activity. Predicted to act upstream of or within phosphatidylserine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human PTDSS2 (phosphatidylserine synthase 2). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Brain (RPKM 90.3), Kidney (RPKM 88.0) and 9 other tissues See more
Orthologs
human mouse all
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See Ptdss2 in Genome Data Viewer
Location:
1q41
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205671024..205695556)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196241439..196267632)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214122981..214148011)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485202 Neighboring gene anoctamin 9 Neighboring gene uncharacterized LOC102552971 Neighboring gene ribonuclease/angiogenin inhibitor 1 Neighboring gene U6 spliceosomal RNA Neighboring gene HRas proto-oncogene, GTPase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Defining the importance of phosphatidylserine synthase 2 in mice. Bergo MO, et al. J Biol Chem, 2002 Dec 6. PMID 12361952
  2. Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes. Stone SJ, et al. J Biol Chem, 2000 Nov 3. PMID 10938271
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylserine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylserine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylserine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylserine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
phosphatidylserine synthase 2
Names
ptdSer synthase 2
serine-exchange enzyme II
NP_001099786.1
XP_038963828.1
XP_063142634.1
XP_063142638.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106316.1 → NP_001099786.1  phosphatidylserine synthase 2

    See identical proteins and their annotated locations for NP_001099786.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/Swiss-Prot
    B2GV22
    UniProtKB/TrEMBL
    A0A8I6AS39
    Related
    ENSRNOP00000021925.3, ENSRNOT00000021925.6
    Conserved Domains (1) summary
    pfam03034
    Location:98 → 378
    PSS; Phosphatidyl serine synthase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    205671024..205695556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286564.1 → XP_063142634.1  phosphatidylserine synthase 2 isoform X2

  2. XM_039107900.2 → XP_038963828.1  phosphatidylserine synthase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AS39
    Conserved Domains (1) summary
    pfam03034
    Location:86 → 366
    PSS; Phosphatidyl serine synthase

  3. XM_063286568.1 → XP_063142638.1  phosphatidylserine synthase 2 isoform X3

    UniProtKB/TrEMBL
    A6HXP9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2GV22.1 GenPept UniProtKB/Swiss-Prot:B2GV22

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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