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Smad2 SMAD family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29357, updated on 10-Jul-2024

Summary

Official Symbol
Smad2provided by RGD
Official Full Name
SMAD family member 2provided by RGD
Primary source
RGD:3031
See related
EnsemblRapid:ENSRNOG00000018140 AllianceGenome:RGD:3031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Madh2
Summary
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; SMAD binding activity; and enzyme binding activity. Predicted to contribute to DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including adrenal gland development; regulation of gene expression; and transforming growth factor beta receptor signaling pathway. Located in cytoplasm and nucleus. Part of protein-containing complex. Used to study hepatocellular carcinoma. Biomarker of colon cancer and myocardial infarction. Human ortholog(s) of this gene implicated in Lynch syndrome; cervical cancer; and ovarian cancer. Orthologous to human SMAD2 (SMAD family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 158.7), Lung (RPKM 157.7) and 9 other tissues See more
Orthologs
NEW
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Genomic context

See Smad2 in Genome Data Viewer
Location:
18q12.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (72124792..72193345)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (69849884..69918926)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (72550107..72612078)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098205 Neighboring gene uncharacterized LOC134483052 Neighboring gene uncharacterized LOC102556385 Neighboring gene zinc finger and BTB domain containing 7C Neighboring gene large ribosomal subunit protein eL15-like Neighboring gene uncharacterized LOC102549578 Neighboring gene uncharacterized LOC120098188

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC156656

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
contributes_to DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables I-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables I-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables co-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tau protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type I transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in activin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adrenal gland development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
 
involved_in anterior/posterior pattern specification ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in aortic valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in determination of left/right asymmetry in lateral mesoderm ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within developmental growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic foregut morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic pattern specification ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cushion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endoderm development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endoderm formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within gastrulation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within insulin secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within lung development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesoderm formation ISO
Inferred from Sequence Orthology
more info
 
involved_in mesoderm formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in nodal signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in odontoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in odontoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within organ growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pancreas development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within paraxial mesoderm morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in paraxial mesoderm morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within pattern specification process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pericardium development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in pulmonary valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cholesterol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to glucose ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to transforming growth factor beta ISO
Inferred from Sequence Orthology
more info
 
involved_in secondary palate development ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction involved in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
involved_in zygotic specification of dorsal/ventral axis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of SMAD protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of activin responsive factor complex ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of heteromeric SMAD protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heteromeric SMAD protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of homomeric SMAD protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
mothers against decapentaplegic homolog 2
Names
SMAD 2
mad-related protein 2
mothers against DPP homolog 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277450.1NP_001264379.1  mothers against decapentaplegic homolog 2

    See identical proteins and their annotated locations for NP_001264379.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC127497, JAXUCZ010000018
    UniProtKB/Swiss-Prot
    A0JPM1, O70436
    UniProtKB/TrEMBL
    A0A8L2QQK5, A6KMS7
    Related
    ENSRNOP00000048329.5, ENSRNOT00000046847.6
    Conserved Domains (2) summary
    cd10985
    Location:266456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    cl00055
    Location:8172
    MH1; N-terminal Mad Homology 1 (MH1) domain
  2. NM_019191.2NP_062064.1  mothers against decapentaplegic homolog 2

    See identical proteins and their annotated locations for NP_062064.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB010147, JAXUCZ010000018
    UniProtKB/Swiss-Prot
    A0JPM1, O70436
    UniProtKB/TrEMBL
    A0A8L2QQK5, A6KMS7
    Related
    ENSRNOP00000105745.1, ENSRNOT00000122336.1
    Conserved Domains (2) summary
    cd10985
    Location:266456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    cl00055
    Location:8172
    MH1; N-terminal Mad Homology 1 (MH1) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    72124792..72193345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277279.1XP_063133349.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/Swiss-Prot
    A0JPM1, O70436
    UniProtKB/TrEMBL
    A0A8L2QQK5, A6KMS7
  2. XM_006254945.5XP_006255007.1  mothers against decapentaplegic homolog 2 isoform X2

    See identical proteins and their annotated locations for XP_006255007.1

    UniProtKB/TrEMBL
    A0A0G2K0P2, A0A8I6ASQ0, A6KMS9
    Related
    ENSRNOP00000071524.2, ENSRNOT00000089468.3
    Conserved Domains (2) summary
    cd10491
    Location:8142
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:236426
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
  3. XM_063277280.1XP_063133350.1  mothers against decapentaplegic homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K0P2, A0A8I6ASQ0, A6KMS9
    Related
    ENSRNOP00000097880.2, ENSRNOT00000109129.2
  4. XM_006254946.5XP_006255008.1  mothers against decapentaplegic homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZQC4, A0A8I5ZS20
    Related
    ENSRNOP00000075341.2, ENSRNOT00000092173.3
    Conserved Domains (2) summary
    cd10985
    Location:210400
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    cl00055
    Location:53116
    MH1; N-terminal Mad Homology 1 (MH1) domain