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Nkx1-2 NK1 homeobox 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293568, updated on 24-Apr-2022

Summary

Official Symbol
Nkx1-2provided by RGD
Official Full Name
NK1 homeobox 2provided by RGD
Primary source
RGD:1306744
See related
Ensembl:ENSRNOG00000017006 AllianceGenome:RGD:1306744
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human NKX1-2 (NK1 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 20.7), Liver (RPKM 9.2) and 3 other tissues See more
Orthologs
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Genomic context

See Nkx1-2 in Genome Data Viewer
Location:
1q41
Exon count:
2
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (187388711..187391149, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (204603116..204605552, complement)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene ornithine aminotransferase Neighboring gene phospholysine phosphohistidine inorganic pyrophosphate phosphatase Neighboring gene uncharacterized LOC120099944 Neighboring gene uncharacterized LOC120099945

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NK1 transcription factor-related protein 2
Names
NK1 transcription factor related, locus 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170476.1NP_001163947.1  NK1 transcription factor-related protein 2

    See identical proteins and their annotated locations for NP_001163947.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000044
    UniProtKB/TrEMBL
    D3Z9E2
    Related
    ENSRNOP00000022904.3, ENSRNOT00000022904.5
    Conserved Domains (1) summary
    pfam00046
    Location:160213
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    187388711..187391149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)