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Fgf8 fibroblast growth factor 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29349, updated on 13-Apr-2024

Summary

Official Symbol
Fgf8provided by RGD
Official Full Name
fibroblast growth factor 8provided by RGD
Primary source
RGD:70891
See related
Ensembl:ENSRNOG00000017524 AllianceGenome:RGD:70891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fgf6c
Summary
Enables chemoattractant activity. Involved in several processes, including neuron development; odontogenesis; and response to oxidative stress. Located in external side of plasma membrane. Biomarker of hypospadias. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 6 with or without anosmia and prostate carcinoma in situ. Orthologous to human FGF8 (fibroblast growth factor 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 2.0), Testes (RPKM 1.2) and 5 other tissues See more
Orthologs
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Genomic context

See Fgf8 in Genome Data Viewer
Location:
1q54
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (254533504..254539605, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (244584477..244590578, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (265492949..265498965, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene F-box and WD repeat domain containing 4 Neighboring gene uncharacterized LOC102550220 Neighboring gene nucleophosmin/nucleoplasmin, 3 Neighboring gene O-GlcNAcase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chemoattractant activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables type 1 fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type 1 fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type 2 fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type 2 fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in bone development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell migration involved in mesendoderm migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell proliferation in forebrain ISO
Inferred from Sequence Orthology
more info
 
involved_in central nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within corticotropin hormone secreting cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
 
involved_in dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in dorsal/ventral axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal/ventral pattern formation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within embryo development ending in birth or egg hatching ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic heart tube development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic neurocranium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial to mesenchymal transition involved in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial to mesenchymal transition involved in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within forebrain dorsal/ventral pattern formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within forebrain morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in forebrain neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within generation of neurons ISO
Inferred from Sequence Orthology
more info
 
involved_in gonad development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart looping ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within larynx morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within male genitalia development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesodermal cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in mesonephros development ISO
Inferred from Sequence Orthology
more info
 
involved_in metanephros development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within midbrain-hindbrain boundary development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural plate morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in neuroepithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in odontogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of organ growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within organ induction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within otic vesicle formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pallium development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pharyngeal system development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of organ growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within signal transduction involved in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within subpallium development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within telencephalon development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within thyroid gland development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within thyroid-stimulating hormone-secreting cell differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fibroblast growth factor 8
Names
fibroblast growth factor 6c
fibroblast growth factor 8 (androgen-induced)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414191.1NP_001401120.1  fibroblast growth factor 8 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
  2. NM_133286.2NP_579820.1  fibroblast growth factor 8 isoform 2 precursor

    See identical proteins and their annotated locations for NP_579820.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8J8XTJ6, D4A7C7, Q76LI5
    Related
    ENSRNOP00000023558.4, ENSRNOT00000023558.4
    Conserved Domains (1) summary
    pfam00167
    Location:41164
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    254533504..254539605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107310.1XP_038963238.1  fibroblast growth factor 8 isoform X2

    Conserved Domains (1) summary
    pfam00167
    Location:134257
    FGF; Fibroblast growth factor
  2. XM_063286101.1XP_063142171.1  fibroblast growth factor 8 isoform X1