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Fgf7 fibroblast growth factor 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29348, updated on 18-Sep-2024

Summary

Official Symbol
Fgf7provided by RGD
Official Full Name
fibroblast growth factor 7provided by RGD
Primary source
RGD:61805
See related
EnsemblRapid:ENSRNOG00000009425 AllianceGenome:RGD:61805
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kgf; Fgf5b; KGF/FGF7
Summary
Enables growth factor activity; heparin binding activity; and type 2 fibroblast growth factor receptor binding activity. Involved in several processes, including ovarian follicle development; phosphatidylcholine biosynthetic process; and surfactant homeostasis. Located in extracellular space. Orthologous to human FGF7 (fibroblast growth factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 81.8), Lung (RPKM 48.2) and 9 other tissues See more
Orthologs
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Genomic context

See Fgf7 in Genome Data Viewer
Location:
3q36
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (133734557..133786678)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (113280448..113333279)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (118315859..118368464)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 2 Neighboring gene galactokinase 2 Neighboring gene family with sequence similarity 227, member B Neighboring gene DTW domain containing 1 Neighboring gene ATPase phospholipid transporting 8B4 (putative)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chemoattractant activity IEA
Inferred from Electronic Annotation
more info
 
enables chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables type 2 fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type 2 fibroblast growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in branching involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hair follicle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in lung development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in myoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylcholine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation involved in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of keratinocyte migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of keratinocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of synapse maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synapse maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in secretion by lung epithelial cell involved in lung growth IEA
Inferred from Electronic Annotation
more info
 
involved_in secretion by lung epithelial cell involved in lung growth ISO
Inferred from Sequence Orthology
more info
 
involved_in surfactant homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fibroblast growth factor 7
Names
FGF-7
HBGF-7
Keratinocyte Growth Factor Fgf-7
fibroblast growth factor 5b
heparin-binding growth factor 7

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022182.1NP_071518.1  fibroblast growth factor 7 precursor

    See identical proteins and their annotated locations for NP_071518.1

    Status: PROVISIONAL

    Source sequence(s)
    X56551
    UniProtKB/Swiss-Prot
    Q02195
    UniProtKB/TrEMBL
    Q9ERN5
    Conserved Domains (1) summary
    smart00442
    Location:63191
    FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    133734557..133786678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234903.5XP_006234965.1  fibroblast growth factor 7 isoform X1

    See identical proteins and their annotated locations for XP_006234965.1

    UniProtKB/TrEMBL
    A6HPY1, G3V775, Q9ERN5
    Related
    ENSRNOP00000012700.2, ENSRNOT00000012700.6
    Conserved Domains (1) summary
    pfam00167
    Location:65189
    FGF; Fibroblast growth factor
  2. XM_039104434.2XP_038960362.1  fibroblast growth factor 7 isoform X1

    UniProtKB/TrEMBL
    A6HPY1, G3V775, Q9ERN5
    Conserved Domains (1) summary
    pfam00167
    Location:65189
    FGF; Fibroblast growth factor