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Uqcrc2 ubiquinol cytochrome c reductase core protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293448, updated on 9-Dec-2024

Summary

Official Symbol
Uqcrc2provided by RGD
Official Full Name
ubiquinol cytochrome c reductase core protein 2provided by RGD
Primary source
RGD:1359150
See related
EnsemblRapid:ENSRNOG00000036742 AllianceGenome:RGD:1359150
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metal ion binding activity and metalloendopeptidase activity. Involved in response to xenobiotic stimulus. Part of respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 5. Orthologous to human UQCRC2 (ubiquinol-cytochrome c reductase core protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Heart (RPKM 3931.5), Muscle (RPKM 2363.5) and 9 other tissues See more
Orthologs
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Genomic context

See Uqcrc2 in Genome Data Viewer
Location:
1q36
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (184599240..184629804)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (175167933..175198499)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (190555177..190585741)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor 116 like, pseudogene 36 Neighboring gene ankyrin repeat domain 62 like Neighboring gene ribosomal protein L36, pseudogene Neighboring gene large ribosomal subunit protein eL36-like Neighboring gene PDZ domain containing 9 Neighboring gene small nucleolar RNA U13 Neighboring gene modulator of smoothened Neighboring gene large ribosomal subunit protein uL10-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC94368

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of respiratory chain complex III IDA
Inferred from Direct Assay
more info
PubMed 
part_of respiratory chain complex III ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytochrome b-c1 complex subunit 2, mitochondrial
Names
complex III subunit 2
core protein II
ubiquinol-cytochrome C reductase complex core protein 2, mitochondrial precursor (Complex III subunit II)
ubiquinol-cytochrome c reductase core protein II
ubiquinol-cytochrome-c reductase complex core protein 2
NP_001006971.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006970.1NP_001006971.1  cytochrome b-c1 complex subunit 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001006971.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083610
    UniProtKB/Swiss-Prot
    P32551, Q5XIR3
    UniProtKB/TrEMBL
    A0A8I6A888, A6I8R0
    Related
    ENSRNOP00000021514.4, ENSRNOT00000021514.7
    Conserved Domains (1) summary
    COG0612
    Location:30435
    PqqL; Predicted Zn-dependent peptidase [General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    184599240..184629804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)