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Prkce protein kinase C, epsilon [ Rattus norvegicus (Norway rat) ]

Gene ID: 29340, updated on 22-Nov-2020

Summary

Official Symbol
Prkceprovided by RGD
Official Full Name
protein kinase C, epsilonprovided by RGD
Primary source
RGD:61925
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pkce
Summary
has phospholipid and diacylglycerol-dependent activity; plays a role in ouabain induced Na+/K+-ATPase mediated signal transduction in cardiac myocytes [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in Brain (RPKM 183.2), Heart (RPKM 82.1) and 9 other tissues See more
Orthologs

Genomic context

See Prkce in Genome Data Viewer
Location:
6q12
Exon count:
17
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (9483400..9973396)
106 current Rn_Celera (GCF_000002265.2) 6 AC_000074.1 (7696161..8179574, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (9404548..9883579)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene S1 RNA binding domain 1 Neighboring gene uncharacterized LOC102551445 Neighboring gene phosphoglycerate mutase 1-like Neighboring gene RGD1562146 Neighboring gene uncharacterized LOC102557388 Neighboring gene eukaryotic translation initiation factor 3, subunit H Neighboring gene endothelial PAS domain protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
actin monomer binding ISO
Inferred from Sequence Orthology
more info
 
actin monomer binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium-dependent protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
calcium-independent protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
enzyme activator activity ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
ethanol binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor activator activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
TRAM-dependent toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
TRAM-dependent toll-like receptor 4 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to ethanol ISO
Inferred from Sequence Orthology
more info
 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cellular response to platelet-derived growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to prostaglandin E stimulus ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
lipopolysaccharide-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
locomotory exploration behavior ISO
Inferred from Sequence Orthology
more info
 
macrophage activation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mitochondrial calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
negative regulation of release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular glucuronidation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mucus secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
positive regulation of wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic vesicle exocytosis EXP
Inferred from Experiment
more info
PubMed 
response to morphine ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
cell periphery ISO
Inferred from Sequence Orthology
more info
 
cell periphery ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction EXP
Inferred from Experiment
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
presynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein kinase C epsilon type
Names
nPKC-epsilon
NP_058867.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017171.1NP_058867.1  protein kinase C epsilon type

    See identical proteins and their annotated locations for NP_058867.1

    Status: PROVISIONAL

    Source sequence(s)
    M18331
    UniProtKB/Swiss-Prot
    P09216
    Conserved Domains (4) summary
    cd04014
    Location:3135
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    smart00220
    Location:408668
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:412732
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:243295
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    9483400..9973396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    7696161..8179574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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