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GSN gelsolin [ Homo sapiens (human) ]

Gene ID: 2934, updated on 27-Nov-2024

Summary

Official Symbol
GSNprovided by HGNC
Official Full Name
gelsolinprovided by HGNC
Primary source
HGNC:HGNC:4620
See related
Ensembl:ENSG00000148180 MIM:137350; AllianceGenome:HGNC:4620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADF; AGEL; AMYLD4
Summary
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 444.2), heart (RPKM 172.6) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GSN in Genome Data Viewer
Location:
9q33.2
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (121201483..121332842)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (133397510..133528852)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (123963761..124095120)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene complement C5 Neighboring gene uncharacterized LOC124902261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28914 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:123836497-123836693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28917 Neighboring gene NANOG hESC enhancer GRCh37_chr9:123883693-123884194 Neighboring gene centriolin Neighboring gene uncharacterized LOC124902357 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20231 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:123963761-123964260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28920 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:123983210-123983860 Neighboring gene RNA, 7SL, cytoplasmic 181, pseudogene Neighboring gene RAB14, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28921 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124023585-124024084 Neighboring gene ATPase H+ transporting V1 subunit B2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20233 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:124043752-124044951 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124047035-124047535 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:124048350-124049549 Neighboring gene Sharpr-MPRA regulatory region 178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124056667-124057289 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124061747-124062407 Neighboring gene GSN antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124089303-124090216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28922 Neighboring gene uncharacterized LOC102723324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124132533-124133493 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:124148517-124149463 Neighboring gene stomatin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124215525-124216026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124216027-124216526 Neighboring gene NANOG hESC enhancer GRCh37_chr9:124234601-124235163 Neighboring gene glycoprotein alpha-galactosyltransferase 1 (inactive) Neighboring gene RNA, 7SL, cytoplasmic 187, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of gelsolin by siRNA inhibits early HIV-1 infection and HIV-1 Env (gp120/gp41)-mediated membrane fusion in permissive lymphocytes PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Gelsolin overexpression impairs HIV-1 gp120-induced cortical F-actin reorganization and capping and gp120-mediated CD4-CCR5 and CD4-CXCR4 redistribution in permissive lymphocytes PubMed
Tat tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of gelsolin (GSN) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
vpr The G5 domain of gelsolin inhibits HIV-Vpr-induced T-cell apoptosis by blocking the interaction between Vpr and VDAC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp313L0718

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables myosin II binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatidylinositol 3-kinase catalytic subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin filament capping ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in actin filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin filament severing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament severing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in amyloid fibril formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cardiac muscle cell contraction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to type II interferon IEA
Inferred from Electronic Annotation
more info
 
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagocytosis, engulfment ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of actin nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of keratinocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein processing in phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of establishment of T cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of plasma membrane raft polarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of podosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of receptor clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in relaxation of cardiac muscle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in renal protein absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to muscle stretch ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in sequestering of actin monomers IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in striated muscle atrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in actin cap IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in blood microparticle HDA PubMed 
colocalizes_with cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in focal adhesion HDA PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in podosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
gelsolin
Names
actin-depolymerizing factor
brevin
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012872.2 RefSeqGene

    Range
    72081..136761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000177.5NP_000168.1  gelsolin isoform a precursor

    See identical proteins and their annotated locations for NP_000168.1

    Status: REVIEWED

    Source sequence(s)
    BC026033, DB250757
    Consensus CDS
    CCDS6828.1
    UniProtKB/Swiss-Prot
    A2A418, A8MUD1, A8MYN7, B7Z373, B7Z5V1, F5H1A8, P06396, Q5T0I2, Q8WVV7
    UniProtKB/TrEMBL
    A0A384MEF1, B7Z9A0
    Related
    ENSP00000362924.4, ENST00000373818.8
    Conserved Domains (6) summary
    cd11288
    Location:561649
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:186275
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:59171
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:666764
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:295395
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:439539
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  2. NM_001127662.2NP_001121134.1  gelsolin isoform b

    See identical proteins and their annotated locations for NP_001121134.1

    Status: REVIEWED

    Source sequence(s)
    AK096280, BC017491, DA450851
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  3. NM_001127663.2NP_001121135.2  gelsolin isoform f

    Status: REVIEWED

    Source sequence(s)
    AK096280, BC017491, DA294394, DA394782
    Consensus CDS
    CCDS75890.1
    UniProtKB/TrEMBL
    A0A0A0MT01, B7Z6N2
    Related
    ENSP00000409358.2, ENST00000449733.7
    Conserved Domains (6) summary
    cd11288
    Location:546634
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:171260
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:44156
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:651749
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:280380
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:424524
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  4. NM_001127664.2NP_001121136.1  gelsolin isoform b

    See identical proteins and their annotated locations for NP_001121136.1

    Status: REVIEWED

    Source sequence(s)
    AK096280, BC017491, DA294394, DB170452
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  5. NM_001127665.2NP_001121137.1  gelsolin isoform b

    See identical proteins and their annotated locations for NP_001121137.1

    Status: REVIEWED

    Source sequence(s)
    AK096280, BC017491, DC370937
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  6. NM_001127666.2NP_001121138.1  gelsolin isoform c

    See identical proteins and their annotated locations for NP_001121138.1

    Status: REVIEWED

    Source sequence(s)
    AK096280, BC017491, DC341948
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Related
    ENSP00000362914.3, ENST00000373808.8
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  7. NM_001127667.2NP_001121139.1  gelsolin isoform c

    See identical proteins and their annotated locations for NP_001121139.1

    Status: REVIEWED

    Source sequence(s)
    AK096280, BC017491, DC316173
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  8. NM_001258029.2NP_001244958.1  gelsolin isoform d

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS75891.1
    UniProtKB/TrEMBL
    A0A0A0MS51, B7Z992
    Related
    ENSP00000377882.3, ENST00000394353.7
    Conserved Domains (6) summary
    cd11288
    Location:527615
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:152241
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:25137
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:632730
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:261361
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:405505
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  9. NM_001258030.2NP_001244959.1  gelsolin isoform e

    Status: REVIEWED

    Source sequence(s)
    AK295572, AK299453, AL513122, BC017491, DC378873
    Consensus CDS
    CCDS65118.1
    UniProtKB/TrEMBL
    B7Z992
    Related
    ENSP00000445823.1, ENST00000545652.6
    Conserved Domains (6) summary
    cd11288
    Location:518606
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:143232
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:16128
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:623721
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:252352
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:396496
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  10. NM_001353053.1NP_001339982.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL137068, AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  11. NM_001353054.1NP_001339983.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL137068, AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Related
    ENSP00000362929.2, ENST00000373823.7
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  12. NM_001353055.2NP_001339984.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  13. NM_001353056.2NP_001339985.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  14. NM_001353057.2NP_001339986.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  15. NM_001353058.2NP_001339987.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  16. NM_001353059.2NP_001339988.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  17. NM_001353060.2NP_001339989.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  18. NM_001353061.2NP_001339990.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  19. NM_001353062.1NP_001339991.1  gelsolin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  20. NM_001353063.2NP_001339992.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  21. NM_001353064.2NP_001339993.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  22. NM_001353065.2NP_001339994.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  23. NM_001353066.2NP_001339995.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  24. NM_001353067.2NP_001339996.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  25. NM_001353068.2NP_001339997.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  26. NM_001353069.2NP_001339998.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  27. NM_001353070.2NP_001339999.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  28. NM_001353071.2NP_001340000.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  29. NM_001353072.2NP_001340001.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  30. NM_001353073.2NP_001340002.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  31. NM_001353074.2NP_001340003.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  32. NM_001353075.1NP_001340004.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  33. NM_001353076.2NP_001340005.1  gelsolin isoform g

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS94475.1
    UniProtKB/TrEMBL
    A0A8V8TND7, B7Z9A0
    Related
    ENSP00000514432.1, ENST00000699558.1
    Conserved Domains (6) summary
    cd11288
    Location:534622
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:159248
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:32144
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:639737
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:268368
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:412512
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  34. NM_001353077.1NP_001340006.1  gelsolin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL513122
    Consensus CDS
    CCDS48011.1
    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  35. NM_001353078.2NP_001340007.1  gelsolin isoform h

    Status: REVIEWED

    Source sequence(s)
    AL513122
    UniProtKB/TrEMBL
    B3KS49
    Conserved Domains (4) summary
    cd11288
    Location:292380
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:397495
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:26126
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:170270
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  36. NM_198252.3NP_937895.1  gelsolin isoform b

    See identical proteins and their annotated locations for NP_937895.1

    Status: REVIEWED

    Source sequence(s)
    AK096280, BC017491
    Consensus CDS
    CCDS6829.1
    UniProtKB/TrEMBL
    B7Z992
    Related
    ENSP00000404226.2, ENST00000432226.7
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    121201483..121332842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423273.1XP_047279229.1  gelsolin isoform X5

  2. XM_047423267.1XP_047279223.1  gelsolin isoform X4

  3. XM_047423268.1XP_047279224.1  gelsolin isoform X4

  4. XM_047423272.1XP_047279228.1  gelsolin isoform X5

  5. XM_047423265.1XP_047279221.1  gelsolin isoform X1

  6. XM_017014645.2XP_016870134.1  gelsolin isoform X3

    UniProtKB/TrEMBL
    B7Z9A0
    Conserved Domains (6) summary
    cd11288
    Location:531619
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:156245
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:29141
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:636734
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:265365
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:409509
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  7. XM_047423271.1XP_047279227.1  gelsolin isoform X4

  8. XM_011518585.2XP_011516887.1  gelsolin isoform X2

    UniProtKB/TrEMBL
    B7Z9A0
    Conserved Domains (6) summary
    cd11288
    Location:540628
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:165254
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:38150
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:645743
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:274374
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:418518
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  9. XM_047423270.1XP_047279226.1  gelsolin isoform X4

  10. XM_047423266.1XP_047279222.1  gelsolin isoform X3

  11. XM_047423269.1XP_047279225.1  gelsolin isoform X4

  12. XM_005251944.2XP_005252001.1  gelsolin isoform X4

    See identical proteins and their annotated locations for XP_005252001.1

    UniProtKB/TrEMBL
    B7Z992
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  13. XM_011518594.2XP_011516896.1  gelsolin isoform X6

    Conserved Domains (5) summary
    cd11288
    Location:352440
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:457555
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:86186
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:230330
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1266
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    133397510..133528852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362811.1XP_054218786.1  gelsolin isoform X1

  2. XM_054362812.1XP_054218787.1  gelsolin isoform X1

  3. XM_054362815.1XP_054218790.1  gelsolin isoform X3

  4. XM_054362818.1XP_054218793.1  gelsolin isoform X4

  5. XM_054362813.1XP_054218788.1  gelsolin isoform X2

  6. XM_054362817.1XP_054218792.1  gelsolin isoform X4

  7. XM_054362814.1XP_054218789.1  gelsolin isoform X3

  8. XM_054362816.1XP_054218791.1  gelsolin isoform X4

  9. XM_054362819.1XP_054218794.1  gelsolin isoform X6