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GSN gelsolin [ Homo sapiens (human) ]

Gene ID: 2934, updated on 19-Jul-2017
Official Symbol
GSNprovided by HGNC
Official Full Name
gelsolinprovided by HGNC
Primary source
HGNC:HGNC:4620
See related
Ensembl:ENSG00000148180 MIM:137350; Vega:OTTHUMG00000020584
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADF; AGEL
Summary
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
9q33.2
Exon count:
37
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (121201082..121332844)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (124030380..124095122)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene TNF receptor associated factor 1 Neighboring gene complement C5 Neighboring gene centriolin Neighboring gene RNA, 7SL, cytoplasmic 181, pseudogene Neighboring gene RAB14, member RAS oncogene family Neighboring gene ATPase H+ transporting V1 subunit B2 pseudogene Neighboring gene GSN antisense RNA 1 Neighboring gene uncharacterized LOC102723324 Neighboring gene stomatin

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of gelsolin by siRNA inhibits early HIV-1 infection and HIV-1 Env (gp120/gp41)-mediated membrane fusion in permissive lymphocytes PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Gelsolin overexpression impairs HIV-1 gp120-induced cortical F-actin reorganization and capping and gp120-mediated CD4-CCR5 and CD4-CXCR4 redistribution in permissive lymphocytes PubMed
Tat tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of gelsolin (GSN) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
vpr The G5 domain of gelsolin inhibits HIV-Vpr-induced T-cell apoptosis by blocking the interaction between Vpr and VDAC PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp313L0718

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
myosin II binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament capping ISS
Inferred from Sequence or Structural Similarity
more info
 
actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
actin filament reorganization IGI
Inferred from Genetic Interaction
more info
PubMed 
actin filament severing IDA
Inferred from Direct Assay
more info
PubMed 
actin filament severing IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament severing ISS
Inferred from Sequence or Structural Similarity
more info
 
actin nucleation IEA
Inferred from Electronic Annotation
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
amyloid fibril formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
barbed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
oligodendrocyte development IEA
Inferred from Electronic Annotation
more info
 
phagocytosis, engulfment ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of keratinocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein processing in phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
protein destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of establishment of T cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of plasma membrane raft polarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of podosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of receptor clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of wound healing, spreading of epidermal cells IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of wound healing, spreading of epidermal cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
renal protein absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to folic acid IEA
Inferred from Electronic Annotation
more info
 
sequestering of actin monomers IMP
Inferred from Mutant Phenotype
more info
PubMed 
striated muscle atrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cap IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
blood microparticle IDA
Inferred from Direct Assay
more info
PubMed 
cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
podosome IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IEA
Inferred from Electronic Annotation
more info
 
sarcoplasm IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule lumen TAS
Traceable Author Statement
more info
 
Preferred Names
gelsolin
Names
actin-depolymerizing factor
brevin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012872.2 RefSeqGene

    Range
    72021..136761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000177.4NP_000168.1  gelsolin isoform a precursor

    See identical proteins and their annotated locations for NP_000168.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC026033, DB250757
    Consensus CDS
    CCDS6828.1
    UniProtKB/Swiss-Prot
    P06396
    Related
    ENSP00000362924.4, OTTHUMP00000022011, ENST00000373818.8, OTTHUMT00000053861
    Conserved Domains (6) summary
    cd11288
    Location:561649
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:186275
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:59171
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:666764
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:295395
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:439539
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  2. NM_001127662.1NP_001121134.1  gelsolin isoform b

    See identical proteins and their annotated locations for NP_001121134.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a. Variants 2, 3, 5, 6, and 11-20 all encode isoform b.
    Source sequence(s)
    AK096280, BC017491, DA294394, DA450851
    Consensus CDS
    CCDS6829.1
    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  3. NM_001127663.1NP_001121135.2  gelsolin isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (f) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK096280, BC017491, DA294394, DA394782
    Consensus CDS
    CCDS75890.1
    UniProtKB/Swiss-Prot
    P06396
    UniProtKB/TrEMBL
    A0A0A0MT01
    Related
    ENSP00000409358.2, ENST00000449733.7
    Conserved Domains (6) summary
    cd11288
    Location:546634
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:171260
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:44156
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:651749
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:280380
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:424524
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  4. NM_001127664.1NP_001121136.1  gelsolin isoform b

    See identical proteins and their annotated locations for NP_001121136.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a. Variants 2, 3, 5, 6, and 11-20 all encode isoform b.
    Source sequence(s)
    AK096280, BC017491, DA294394, DB170452
    Consensus CDS
    CCDS6829.1
    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  5. NM_001127665.1NP_001121137.1  gelsolin isoform b

    See identical proteins and their annotated locations for NP_001121137.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a. Variants 2, 3, 5, 6, and 11-20 all encode isoform b.
    Source sequence(s)
    AK096280, BC017491, DA294394, DC370937
    Consensus CDS
    CCDS6829.1
    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  6. NM_001127666.1NP_001121138.1  gelsolin isoform c

    See identical proteins and their annotated locations for NP_001121138.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 7, 8, 21-33, and 35 all encode isoform c.
    Source sequence(s)
    AK096280, BC017491, DA294394, DC341948
    Consensus CDS
    CCDS48011.1
    UniProtKB/Swiss-Prot
    P06396
    Related
    ENSP00000362914.3, ENST00000373808.8
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  7. NM_001127667.1NP_001121139.1  gelsolin isoform c

    See identical proteins and their annotated locations for NP_001121139.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 7, 8, 21-33, and 35 all encode isoform c.
    Source sequence(s)
    AK096280, BC017491, DA294394, DC316173
    Consensus CDS
    CCDS48011.1
    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  8. NM_001258029.1NP_001244958.1  gelsolin isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) uses an alternate first exon compared to that of variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK295572, AK297870, BC017491, DA823796
    Consensus CDS
    CCDS75891.1
    UniProtKB/Swiss-Prot
    P06396
    UniProtKB/TrEMBL
    A0A0A0MS51, B7Z4U6
    Related
    ENSP00000377882.3, OTTHUMP00000281153, ENST00000394353.7, OTTHUMT00000488009
    Conserved Domains (6) summary
    cd11288
    Location:527615
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:152241
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:25137
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:632730
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:261361
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:405505
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  9. NM_001258030.1NP_001244959.1  gelsolin isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate first exon compared to that of variant 1. The resulting isoform (e) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK295572, AK299453, BC017491, DC378873
    Consensus CDS
    CCDS65118.1
    UniProtKB/Swiss-Prot
    P06396
    Related
    ENSP00000445823.1, OTTHUMP00000281154, ENST00000545652.6, OTTHUMT00000488010
    Conserved Domains (6) summary
    cd11288
    Location:518606
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:143232
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:16128
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:623721
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:252352
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:396496
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  10. NM_001353053.1NP_001339982.1  gelsolin isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 2, 3, 5, 6, and 12-20, encodes isoform b.
    Source sequence(s)
    AL137068, AL513122
  11. NM_001353054.1NP_001339983.1  gelsolin isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 2, 3, 5, 6, 11, and 13-20, encodes isoform b.
    Source sequence(s)
    AL137068, AL513122
  12. NM_001353055.1NP_001339984.1  gelsolin isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 2, 3, 5, 6, 11, 12, and 14-20, encodes isoform b.
    Source sequence(s)
    AL513122
  13. NM_001353056.1NP_001339985.1  gelsolin isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 2, 3, 5, 6, 11-13, and 15-20, encodes isoform b.
    Source sequence(s)
    AL513122
  14. NM_001353057.1NP_001339986.1  gelsolin isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 2, 3, 5, 6, 11-14, and 16-20, encodes isoform b.
    Source sequence(s)
    AL513122
  15. NM_001353058.1NP_001339987.1  gelsolin isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 2, 3, 5, 6, 11-15, and 17-20, encodes isoform b.
    Source sequence(s)
    AL513122
  16. NM_001353059.1NP_001339988.1  gelsolin isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 2, 3, 5, 6, 11-16, and 18-20, encodes isoform b.
    Source sequence(s)
    AL513122
  17. NM_001353060.1NP_001339989.1  gelsolin isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 2, 3, 5, 6, 11-17, 19, and 20, encodes isoform b.
    Source sequence(s)
    AL513122
  18. NM_001353061.1NP_001339990.1  gelsolin isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 2, 3, 5, 6, 11-18, and 20, encodes isoform b.
    Source sequence(s)
    AL513122
  19. NM_001353062.1NP_001339991.1  gelsolin isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 2, 3, 5, 6, and 11-19, encodes isoform b.
    Source sequence(s)
    AL513122
  20. NM_001353063.1NP_001339992.1  gelsolin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 7, 8, 22-33, and 35, encodes isoform c.
    Source sequence(s)
    AL513122
  21. NM_001353064.1NP_001339993.1  gelsolin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 7, 8, 21, 23-33, and 35, encodes isoform c.
    Source sequence(s)
    AL513122
  22. NM_001353065.1NP_001339994.1  gelsolin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 7, 8, 21, 22, 24-33, and 35, encodes isoform c.
    Source sequence(s)
    AL513122
  23. NM_001353066.1NP_001339995.1  gelsolin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 7, 8, 21-23, 25-33, and 35, encodes isoform c.
    Source sequence(s)
    AL513122
  24. NM_001353067.1NP_001339996.1  gelsolin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 7, 8, 21-24, 26-33, and 35, encodes isoform c.
    Source sequence(s)
    AL513122
  25. NM_001353068.1NP_001339997.1  gelsolin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 7, 8, 21-25, 27-33, and 35, encodes isoform c.
    Source sequence(s)
    AL513122
  26. NM_001353069.1NP_001339998.1  gelsolin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27), as well as variants 7, 8, 21-26, 28-33, and 35, encodes isoform c.
    Source sequence(s)
    AL513122
  27. NM_001353070.1NP_001339999.1  gelsolin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28), as well as variants 7, 8, 21-27, 29-33, and 35, encodes isoform c.
    Source sequence(s)
    AL513122
  28. NM_001353071.1NP_001340000.1  gelsolin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variants 7, 8, 21-28, 30-33, and 35, encodes isoform c.
    Source sequence(s)
    AL513122
  29. NM_001353072.1NP_001340001.1  gelsolin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variants 7, 8, 21-29, 31-33, and 35, encodes isoform c.
    Source sequence(s)
    AL513122
  30. NM_001353073.1NP_001340002.1  gelsolin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31), as well as variants 7, 8, 21-30, 32, 33, and 35, encodes isoform c.
    Source sequence(s)
    AL513122
  31. NM_001353074.1NP_001340003.1  gelsolin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32), as well as variants 7, 8, 21-31, 33, and 35, encodes isoform c.
    Source sequence(s)
    AL513122
  32. NM_001353075.1NP_001340004.1  gelsolin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (33), as well as variants 7, 8, 21-32, and 35, encodes isoform c.
    Source sequence(s)
    AL513122
  33. NM_001353076.1NP_001340005.1  gelsolin isoform g

    Status: REVIEWED

    Source sequence(s)
    AL513122
  34. NM_001353077.1NP_001340006.1  gelsolin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (35), as well as variants 7, 8, and 21-33, encodes isoform c.
    Source sequence(s)
    AL513122
  35. NM_001353078.1NP_001340007.1  gelsolin isoform h

    Status: REVIEWED

    Source sequence(s)
    AL513122
  36. NM_198252.2NP_937895.1  gelsolin isoform b

    See identical proteins and their annotated locations for NP_937895.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a. Variants 2, 3, 5, 6, and 11-20 all encode isoform b.
    Source sequence(s)
    AK096280, BC017491, DA294394
    Consensus CDS
    CCDS6829.1
    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

    Range
    121201082..121332844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014647.1XP_016870136.1  gelsolin isoform X4

    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  2. XM_017014643.1XP_016870132.1  gelsolin isoform X1

    Conserved Domains (6) summary
    cd11288
    Location:559647
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:184273
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:57169
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:664762
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:293393
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:437537
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  3. XM_011518591.2XP_011516893.1  gelsolin isoform X5

    See identical proteins and their annotated locations for XP_011516893.1

    UniProtKB/Swiss-Prot
    P06396
    Related
    ENSP00000362929.2, OTTHUMP00000162202, ENST00000373823.7, OTTHUMT00000254323
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  4. XM_017014644.1XP_016870133.1  gelsolin isoform X1

    Conserved Domains (6) summary
    cd11288
    Location:559647
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:184273
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:57169
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:664762
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:293393
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:437537
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  5. XM_017014646.1XP_016870135.1  gelsolin isoform X4

    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  6. XM_011518589.2XP_011516891.1  gelsolin isoform X4

    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  7. XM_011518587.2XP_011516889.1  gelsolin isoform X4

    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  8. XM_011518588.2XP_011516890.1  gelsolin isoform X4

    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  9. XM_005251945.3XP_005252002.1  gelsolin isoform X5

    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  10. XM_011518590.2XP_011516892.1  gelsolin isoform X4

    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  11. XM_011518593.1XP_011516895.1  gelsolin isoform X5

    See identical proteins and their annotated locations for XP_011516895.1

    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  12. XM_011518586.1XP_011516888.1  gelsolin isoform X4

    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  13. XM_011518584.1XP_011516886.1  gelsolin isoform X1

    Conserved Domains (6) summary
    cd11288
    Location:559647
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:184273
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:57169
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:664762
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:293393
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:437537
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  14. XM_017014648.1XP_016870137.1  gelsolin isoform X4

    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  15. XM_011518592.1XP_011516894.1  gelsolin isoform X5

    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:244344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  16. XM_011518585.1XP_011516887.1  gelsolin isoform X2

    Conserved Domains (6) summary
    cd11288
    Location:540628
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:165254
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:38150
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:645743
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:274374
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:418518
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  17. XM_006717079.1XP_006717142.1  gelsolin isoform X4

    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  18. XM_017014645.1XP_016870134.1  gelsolin isoform X3

    Conserved Domains (6) summary
    cd11288
    Location:531619
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:156245
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:29141
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:636734
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:265365
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:409509
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  19. XM_005251943.1XP_005252000.1  gelsolin isoform X4

    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  20. XM_005251944.1XP_005252001.1  gelsolin isoform X4

    See identical proteins and their annotated locations for XP_005252001.1

    UniProtKB/Swiss-Prot
    P06396
    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:255355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  21. XM_011518594.1XP_011516896.1  gelsolin isoform X6

    Conserved Domains (5) summary
    cd11288
    Location:352440
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:457555
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:86186
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:230330
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:1266
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

RNA

  1. XR_001746283.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    124177269..124242004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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