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Prdx2 peroxiredoxin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29338, updated on 9-Dec-2018

Summary

Official Symbol
Prdx2provided by RGD
Official Full Name
peroxiredoxin 2provided by RGD
Primary source
RGD:3838
See related
Ensembl:ENSRNOG00000003520
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tdpx1
Summary
protective enzyme against oxidative damage by cellular reactive sulfur species [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 2379.0), Spleen (RPKM 2155.6) and 9 other tissues See more
Orthologs

Genomic context

See Prdx2 in Genome Data Viewer
Location:
19q11
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26084816..26090095)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (37060439..37065718)

Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348915 Neighboring gene retbindin Neighboring gene ribonuclease H2, subunit A Neighboring gene JunB proto-oncogene, AP-1 transcription factor subunit Neighboring gene hook microtubule-tethering protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
antioxidant activity ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thioredoxin peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
thioredoxin peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
homeostasis of number of cells IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells ISO
Inferred from Sequence Orthology
more info
 
hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
 
hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
hydrogen peroxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
leukocyte activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
negative regulation of lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of hydrogen peroxide metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of hydrogen peroxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
 
removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
 
respiratory burst involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
respiratory burst involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
thymus development IEA
Inferred from Electronic Annotation
more info
 
thymus development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
myelin sheath ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxiredoxin-2
Names
TSA
thiol-specific antioxidant protein
thioredoxin peroxidase 1
thioredoxin-dependent peroxide reductase 1
NP_058865.1
XP_006255306.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017169.1NP_058865.1  peroxiredoxin-2

    See identical proteins and their annotated locations for NP_058865.1

    Status: PROVISIONAL

    Source sequence(s)
    U06099
    UniProtKB/Swiss-Prot
    P35704
    Related
    ENSRNOP00000004799.2, ENSRNOT00000004799.5
    Conserved Domains (2) summary
    PTZ00253
    Location:1195
    PTZ00253; tryparedoxin peroxidase; Provisional
    cd03015
    Location:8179
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

    Range
    26084816..26090095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255244.1XP_006255306.1  peroxiredoxin-2 isoform X1

    See identical proteins and their annotated locations for XP_006255306.1

    UniProtKB/Swiss-Prot
    P35704
    UniProtKB/TrEMBL
    A0A0G2JSH9
    Conserved Domains (1) summary
    cd03015
    Location:8179
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

Alternate Rn_Celera

Genomic

  1. AC_000087.1 Alternate Rn_Celera

    Range
    22738487..22743678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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