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Oprk1 opioid receptor, kappa 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29335, updated on 22-Aug-2021

Summary

Official Symbol
Oprk1provided by RGD
Official Full Name
opioid receptor, kappa 1provided by RGD
Primary source
RGD:69426
See related
Ensembl:ENSRNOG00000007647
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Expression
Biased expression in Brain (RPKM 22.9), Thymus (RPKM 5.0) and 1 other tissue See more
Orthologs
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Genomic context

See Oprk1 in Genome Data Viewer
Location:
5q12
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (13860016..13877823, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (13742655..13760460, complement)

Chromosome 5 - NC_051340.1Genomic Context describing neighboring genes Neighboring gene similar to proteasome 26S non-ATPase subunit 12 Neighboring gene endogenous retrovirus group K member 9 Pol protein-like Neighboring gene NHP2 ribonucleoprotein homolog Neighboring gene uncharacterized LOC108350923

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled opioid receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled opioid receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynorphin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynorphin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables dynorphin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor serine/threonine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled opioid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled opioid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting opioid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting opioid receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in behavioral response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in conditioned place preference IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in eating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in estrous cycle IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in maternal behavior IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of luteinizing hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of dopamine secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of eating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of locomotion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of p38MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of saliva secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of saliva secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to acrylamide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to auditory stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cocaine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to insulin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to morphine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sensory perception of pain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sensory perception of temperature stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in integral component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kappa-type opioid receptor
Names
K-OR-1
KOR-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318742.1NP_001305671.1  kappa-type opioid receptor isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    JACYVU010000160
    Conserved Domains (2) summary
    pfam00001
    Location:76330
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:70312
    7tm_4; Olfactory receptor
  2. NM_017167.3NP_058863.1  kappa-type opioid receptor isoform 1

    See identical proteins and their annotated locations for NP_058863.1

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).
    Source sequence(s)
    JACYVU010000160
    UniProtKB/Swiss-Prot
    P34975
    Related
    ENSRNOP00000010255.1, ENSRNOT00000010254.3
    Conserved Domains (2) summary
    pfam00001
    Location:76330
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:70312
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051340.1 Reference mRatBN7.2 Primary Assembly

    Range
    13860016..13877823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109359.1XP_038965287.1  kappa-type opioid receptor isoform X1

    Conserved Domains (1) summary
    cd15091
    Location:111392
    7tmA_Kappa_opioid_R; opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors
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