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Insc INSC, spindle orientation adaptor protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 293166, updated on 11-Apr-2024

Summary

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Official Symbol
Inscprovided by RGD
Official Full Name
INSC, spindle orientation adaptor proteinprovided by RGD
Primary source
RGD:1311379
See related
Ensembl:ENSRNOG00000024712 AllianceGenome:RGD:1311379
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311379
Summary
Predicted to enable cytoskeletal anchor activity and protein domain specific binding activity. Predicted to be involved in several processes, including apical protein localization; establishment of mitotic spindle orientation; and regulation of asymmetric cell division. Predicted to act upstream of or within lung epithelial cell differentiation. Predicted to be located in apical part of cell and plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in apical cortex. Predicted to colocalize with cell cortex. Orthologous to human INSC (INSC spindle orientation adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 53.6), Lung (RPKM 18.4) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q34
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (178427360..178534827)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (168993032..169100438)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (184299200..184407487)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene calcitonin-related polypeptide alpha Neighboring gene calcitonin-related polypeptide, beta Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134485166 Neighboring gene uncharacterized LOC134484912

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. Izaki T, et al. Biochem Biophys Res Commun, 2006 Mar 24. PMID 16458856
  2. Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN). Yuzawa S, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22074847, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytoskeletal anchor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apical protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in asymmetric cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lung epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of asymmetric cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in apical cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein inscuteable homolog
Names
inscuteable homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106285.1 → NP_001099755.1  protein inscuteable homolog

    See identical proteins and their annotated locations for NP_001099755.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473956
    UniProtKB/TrEMBL
    A6I8C1, A6I8C2, D3ZFP7
    Related
    ENSRNOP00000031361.4, ENSRNOT00000030540.6
    Conserved Domains (1) summary
    pfam16748
    Location:70 → 113
    INSC_LBD; Inscuteable LGN-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    178427360..178534827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285287.1 → XP_063141357.1  protein inscuteable homolog isoform X1

  2. XM_039106440.2 → XP_038962368.1  protein inscuteable homolog isoform X4

    UniProtKB/TrEMBL
    A6I8C2
    Conserved Domains (1) summary
    pfam16748
    Location:1 → 19
    INSC_LBD; Inscuteable LGN-binding domain

  3. XM_039106438.2 → XP_038962366.1  protein inscuteable homolog isoform X3

    UniProtKB/TrEMBL
    A6I8C2
    Conserved Domains (1) summary
    pfam16748
    Location:1 → 44
    INSC_LBD; Inscuteable LGN-binding domain

  4. XM_017588972.3 → XP_017444461.1  protein inscuteable homolog isoform X2

    UniProtKB/TrEMBL
    A6I8C2

  5. XM_039106441.2 → XP_038962369.1  protein inscuteable homolog isoform X5

    Conserved Domains (1) summary
    pfam16748
    Location:25 → 68
    INSC_LBD; Inscuteable LGN-binding domain

  6. XM_063285288.1 → XP_063141358.1  protein inscuteable homolog isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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