Adora2b adenosine A2B receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adora2bprovided by RGD
Official Full Name: adenosine A2B receptorprovided by RGD
Primary source: RGD:2050
See related: Ensembl:ENSRNOG00000002922 AllianceGenome:RGD:2050
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G protein-coupled adenosine receptor activity. Involved in several processes, including positive regulation of cAMP/PKA signal transduction; positive regulation of norepinephrine secretion; and regulation of biosynthetic process. Located in cell surface. Orthologous to human ADORA2B (adenosine A2b receptor). [provided by Alliance of Genome Resources, May 2025]
Expression: Biased expression in Lung (RPKM 18.9), Brain (RPKM 17.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q23

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (47439712..47456092)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (46940394..46956772)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (48569563..48586366)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting Adenosine A2b Receptor Promotes Penile Rehabilitation of Refractory Erectile Dysfunction.
Title: Targeting Adenosine A2b Receptor Promotes Penile Rehabilitation of Refractory Erectile Dysfunction.
Blockage of the adenosine A2B receptor prevents cardiac fibroblasts overgrowth in rats with pulmonary arterial hypertension.
Title: Blockage of the adenosine A(2B) receptor prevents cardiac fibroblasts overgrowth in rats with pulmonary arterial hypertension.
Activation of basal forebrain cholinergic neurons improves colonic hyperpermeability through the vagus nerve and adenosine A2B receptors in rats.
Title: Activation of basal forebrain cholinergic neurons improves colonic hyperpermeability through the vagus nerve and adenosine A2B receptors in rats.
A1 and A2b adenosine receptors regulate GPX4 against ferroptosis of cardiomyocytes in myocardial infarction rat model and in vitro.
Title: A(1) and A(2b) adenosine receptors regulate GPX4 against ferroptosis of cardiomyocytes in myocardial infarction rat model and in vitro.
Hypoxia-inducible factor-1alpha protects the liver against ischemia-reperfusion injury by regulating the A2B adenosine receptor.
Title: Hypoxia-inducible factor-1alpha protects the liver against ischemia-reperfusion injury by regulating the A2B adenosine receptor.
Activation of central adenosine A2B receptors mediate brain ghrelin-induced improvement of intestinal barrier function through the vagus nerve in rats.
Title: Activation of central adenosine A2B receptors mediate brain ghrelin-induced improvement of intestinal barrier function through the vagus nerve in rats.
Adenosine A2B receptors inhibit K(+) currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway.
Title: Adenosine A(2B) receptors inhibit K(+) currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway.
Low androgen status inhibits the AKT/eNOS/cGMP signaling pathways and the production of cAMP in the corpus cavernosum of castrated rats by downregulating the expression of A2B receptor with no significant difference in the expression of A2A receptor, and results in decreased of intra-cavernous pressure/mean arterial pressure.
Title: Effect of low androgen status on the expression of adenosine A(2A) and A(2B) receptors in rat penile corpus cavernosum.
these results suggested that activation of A2b receptor could be a novel therapeutic approach to high glucose-induced cardiomyocyte injury.
Title: Activation of adenosine A2b receptor attenuates high glucose-induced apoptosis in H9C2 cells via PI3K/Akt signaling.
The activation of Gs protein-coupled receptors (GsPCRs) and the GsPCRs-independent activation of Gs proteins and adenylyl cyclase by cholera toxin induce stimulation of cell surface adenosine receptors (A2A or A2B adenosine receptors).
Title: Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors.

Submit: New GeneRIF Correction See all GeneRIFs (46)

General gene information

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Markers

RH131534 (e-PCR)
- UniSTS:214817

RH138913 (e-PCR)
- UniSTS:221000

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled adenosine receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled adenosine receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled adenosine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in mast cell degranulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cAMP/PKA signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of catecholamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemokine production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chronic inflammatory response to non-antigenic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of chronic inflammatory response to non-antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of guanylate cyclase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell degranulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of norepinephrine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of steroid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular endothelial growth factor production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in relaxation of vascular associated smooth muscle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within relaxation of vascular associated smooth muscle	ISO Inferred from Sequence Orthology more info
involved_in response to angiotensin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasodilation	IBA Inferred from Biological aspect of Ancestor more info
involved_in vasodilation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenosine receptor A2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017161.2 → NP_058857.2 adenosine receptor A2b

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P29276

UniProtKB/TrEMBL

A6HF93, B1WBR3, F7EVK1

Related

ENSRNOP00000003966.2, ENSRNOT00000003966.5

Conserved Domains (2) summary

cd14964
Location:9 → 35

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:8 → 301

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily