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Anapc15 anaphase promoting complex subunit 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293155, updated on 30-Jul-2025
Official Symbol
Anapc15provided by RGD
Official Full Name
anaphase promoting complex subunit 15provided by RGD
Primary source
RGD:1311634
See related
Ensembl:ENSRNOG00000019936 AllianceGenome:RGD:1311634
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
APC15; RGD1311634
Summary
Predicted to be involved in anaphase-promoting complex-dependent catabolic process; protein polyubiquitination; and regulation of mitotic cell cycle spindle assembly checkpoint. Predicted to be part of anaphase-promoting complex. Orthologous to human ANAPC15 (anaphase promoting complex subunit 15). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Thymus (RPKM 142.8), Testes (RPKM 130.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
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See Anapc15 in Genome Data Viewer
Location:
1q32
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (165650478..165678004)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (156238640..156266005)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (166981738..166985363)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene folate receptor beta Neighboring gene ribosomal protein L12, pseudogene 3 Neighboring gene folate receptor alpha Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Mansfeld J, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926987, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in anaphase-promoting complex-dependent catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein branched polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein branched polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IEA
Inferred from Electronic Annotation
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
part_of anaphase-promoting complex ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
anaphase-promoting complex subunit 15

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170435.1 → NP_001163906.1  anaphase-promoting complex subunit 15

    See identical proteins and their annotated locations for NP_001163906.1

    Status: VALIDATED

    Source sequence(s)
    FM103187, FM137052, JAXUCZ010000001
    UniProtKB/Swiss-Prot
    D3ZQX4, D4ACX3
    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1
    Related
    ENSRNOP00000091579.1, ENSRNOT00000117670.2
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    165650478..165678004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106176.2 → XP_038962104.1  anaphase-promoting complex subunit 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZQX4, D4ACX3
    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  2. XM_063285205.1 → XP_063141275.1  anaphase-promoting complex subunit 15 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1

  3. XM_063285207.1 → XP_063141277.1  anaphase-promoting complex subunit 15 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1

  4. XM_039106196.2 → XP_038962124.1  anaphase-promoting complex subunit 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZQX4, D4ACX3
    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  5. XM_006229861.5 → XP_006229923.1  anaphase-promoting complex subunit 15 isoform X1

    See identical proteins and their annotated locations for XP_006229923.1

    UniProtKB/Swiss-Prot
    D3ZQX4, D4ACX3
    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  6. XM_063285202.1 → XP_063141272.1  anaphase-promoting complex subunit 15 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1

  7. XM_008759705.4 → XP_008757927.1  anaphase-promoting complex subunit 15 isoform X2

    See identical proteins and their annotated locations for XP_008757927.1

    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  8. XM_006229862.5 → XP_006229924.1  anaphase-promoting complex subunit 15 isoform X1

    See identical proteins and their annotated locations for XP_006229924.1

    UniProtKB/Swiss-Prot
    D3ZQX4, D4ACX3
    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  9. XM_039106208.2 → XP_038962136.1  anaphase-promoting complex subunit 15 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  10. XM_063285206.1 → XP_063141276.1  anaphase-promoting complex subunit 15 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1

  11. XM_006229869.5 → XP_006229931.1  anaphase-promoting complex subunit 15 isoform X2

    See identical proteins and their annotated locations for XP_006229931.1

    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  12. XM_017588966.3 → XP_017444455.1  anaphase-promoting complex subunit 15 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  13. XM_039106182.2 → XP_038962110.1  anaphase-promoting complex subunit 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZQX4, D4ACX3
    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  14. XM_017588962.3 → XP_017444451.1  anaphase-promoting complex subunit 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZQX4, D4ACX3
    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  15. XM_039106185.2 → XP_038962113.1  anaphase-promoting complex subunit 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZQX4, D4ACX3
    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  16. XM_006229860.4 → XP_006229922.1  anaphase-promoting complex subunit 15 isoform X1

    See identical proteins and their annotated locations for XP_006229922.1

    UniProtKB/Swiss-Prot
    D3ZQX4, D4ACX3
    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  17. XM_039106173.2 → XP_038962101.1  anaphase-promoting complex subunit 15 isoform X1

    UniProtKB/Swiss-Prot
    D3ZQX4, D4ACX3
    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1
    Conserved Domains (1) summary
    pfam15243
    Location:15 → 73
    ANAPC15; Anaphase-promoting complex subunit 15

  18. XM_039106204.1 → XP_038962132.1  anaphase-promoting complex subunit 15 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15

  19. XM_017588963.2 → XP_017444452.1  anaphase-promoting complex subunit 15 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZYZ2, A6I6Y1
    Conserved Domains (1) summary
    pfam15243
    Location:4 → 62
    ANAPC15; Anaphase-promoting complex subunit 15
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZQX4.1 GenPept UniProtKB/Swiss-Prot:D3ZQX4

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