Alg8 ALG8, alpha-1,3-glucosyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Alg8provided by RGD
Official Full Name: ALG8, alpha-1,3-glucosyltransferaseprovided by RGD
Primary source: RGD:1305468
See related: Ensembl:ENSRNOG00000012292 AllianceGenome:RGD:1305468
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ih and polycystic liver disease 3. Orthologous to human ALG8 (ALG8 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Thymus (RPKM 42.6), Adrenal (RPKM 39.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (161095570..161115533)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (151684344..151704310)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (162342061..162362139)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in dolichol-linked oligosaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dolichol-linked oligosaccharide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dolichol-linked oligosaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation via asparagine	IEA Inferred from Electronic Annotation more info
involved_in protein N-linked glycosylation via asparagine	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

Names: asparagine-linked glycosylation 8 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase); asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase); asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog; dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

NP_001029299.1

EC 2.4.1.265

XP_038961896.1

EC 2.4.1.265

XP_038961899.1

EC 2.4.1.265

XP_038961911.1

EC 2.4.1.265

XP_063141081.1

EC 2.4.1.265

XP_063141092.1

EC 2.4.1.265

XP_063141103.1

EC 2.4.1.265

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034127.1 → NP_001029299.1 probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor

See identical proteins and their annotated locations for NP_001029299.1

Status: PROVISIONAL

Source sequence(s)

BC100614

UniProtKB/TrEMBL

E9PT91, Q497D1

Related

ENSRNOP00000016478.6, ENSRNOT00000016478.8

Conserved Domains (1) summary

pfam03155
Location:22 → 507

Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

161095570..161115533

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105968.2 → XP_038961896.1 probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X1

Conserved Domains (1) summary

pfam03155
Location:22 → 370

Alg6_Alg8; ALG6, ALG8 glycosyltransferase family
XM_063285022.1 → XP_063141092.1 probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X5

UniProtKB/TrEMBL

E9PT91
XM_063285011.1 → XP_063141081.1 probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X4

UniProtKB/TrEMBL

E9PT91
XM_063285033.1 → XP_063141103.1 probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X6
XM_039105971.2 → XP_038961899.1 probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X2

UniProtKB/TrEMBL

E9PT91

Conserved Domains (1) summary

pfam03155
Location:1 → 419

Alg6_Alg8; ALG6, ALG8 glycosyltransferase family
XM_039105983.2 → XP_038961911.1 probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X3

UniProtKB/TrEMBL

A6I689

Conserved Domains (1) summary

cl21590
Location:75 → 264

PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase