Prcp prolylcarboxypeptidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prcpprovided by RGD
Official Full Name: prolylcarboxypeptidaseprovided by RGD
Primary source: RGD:1307842
See related: Ensembl:ENSRNOG00000010630 AllianceGenome:RGD:1307842
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable dipeptidyl-peptidase activity and metallocarboxypeptidase activity. Predicted to be involved in angiogenesis involved in wound healing; regulation of blood vessel endothelial cell migration; and regulation of systemic arterial blood pressure. Predicted to act upstream of or within several processes, including glucose homeostasis; plasma kallikrein-kinin cascade; and regulation of thyroid hormone receptor signaling pathway. Predicted to be located in basal part of cell and lysosome. Predicted to be active in extracellular region. Biomarker of brain infarction. Orthologous to human PRCP (prolylcarboxypeptidase). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Spleen (RPKM 205.9), Adrenal (RPKM 156.5) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 1q32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (156343894..156396295)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (146931487..146983891)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (157701089..157750177)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

chronic ethanol regimen is sufficient to promote the enhanced RAS activity-induced decrease in the production of cardiac collagen via downregulated angiotensinase C, leading to the further deterioration of LV systolic dysfunction in SHRs
Title: Angiotensinase C mRNA and Protein Downregulations Are Involved in Ethanol-Deteriorated Left Ventricular Systolic Dysfunction in Spontaneously Hypertensive Rats.
it appears unlikely that PRCP function is regulated by the renin-angiotensin system or by afterload conditions.
Title: Deficient prolylcarboxypeptidase gene and protein expression in left ventricles of spontaneously hypertensive rats (SHR).
eNOS inhibition in spontaneously hypertensive rats induces or enhances an inverse reciprocal interaction between hypothalamus and left ventricle involving the renin-angiotensin system and vasopressin.
Title: Relationship of angiotensinase and vasopressinase activities between hypothalamus, heart, and plasma in L-NAME-treated WKY and SHR.
PRCP is an important component of melanocortin signaling and weight maintenance via control of active alpha-MSH1-13 levels.
Title: Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents.
Suggest that in renovascular hypertension the repression of increases in systolic blood pressure and reversal of mesenteric artery remodelling by rutaecarpine may be related to increased expression of PRCP.
Title: Involvement of prolylcarboxypeptidase in the effect of rutaecarpine on the regression of mesenteric artery hypertrophy in renovascular hypertensive rats.

Submit: New GeneRIF Correction

General gene information

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Markers

AI451719 (e-PCR)
- UniSTS:164360

AU049686 (e-PCR)
- UniSTS:146132

RH131211 (e-PCR)
- UniSTS:214494

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type exopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angiogenesis involved in wound healing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis involved in wound healing	ISO Inferred from Sequence Orthology more info
involved_in angiotensin maturation	IEA Inferred from Electronic Annotation more info
involved_in angiotensin maturation	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within energy homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within plasma kallikrein-kinin cascade	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood vessel endothelial cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of thyroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basal part of cell	IEA Inferred from Electronic Annotation more info
located_in basal part of cell	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysosomal Pro-X carboxypeptidase

Names: prolylcarboxypeptidase (angiotensinase C)

NP_001099751.2

EC 3.4.16.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106281.4 → NP_001099751.2 lysosomal Pro-X carboxypeptidase precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D4AA31

Related

ENSRNOP00000014271.4, ENSRNOT00000014271.8

Conserved Domains (2) summary

COG0596
Location:101 → 211

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

cl21494
Location:52 → 471

Abhydrolase; alpha/beta hydrolases