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Gata6 GATA binding protein 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29300, updated on 30-Sep-2021

Summary

Official Symbol
Gata6provided by RGD
Official Full Name
GATA binding protein 6provided by RGD
Primary source
RGD:2666
See related
EnsemblRapid:ENSRNOG00000023433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
zinc-finger transcription factor that binds DNA at GATA regions; involved in gene regulation in the stomach [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 211.1), Adrenal (RPKM 136.4) and 6 other tissues See more
Orthologs
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Genomic context

See Gata6 in Genome Data Viewer
Location:
18p13
Exon count:
7
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (2188121..2219532)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (2415821..2447087)

Chromosome 18 - NC_051353.1Genomic Context describing neighboring genes Neighboring gene similar to SDA1 domain containing 1 Neighboring gene uncharacterized LOC100909782 Neighboring gene 40S ribosomal protein S10 pseudogene Neighboring gene uncharacterized LOC120098213

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in animal organ formation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within animal organ formation ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle hypertrophy in response to stress IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac vascular smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac vascular smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to BMP stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to gonadotropin stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to gonadotropin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in club cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within club cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in endodermal cell fate determination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endodermal cell fate determination ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in heart contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in intestinal epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intestinal epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in liver development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
 
involved_in lung saccule development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lung saccule development ISO
Inferred from Sequence Orthology
more info
 
involved_in male gonad development IEA
Inferred from Electronic Annotation
more info
 
involved_in male gonad development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of pri-miRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of sebum secreting cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of sebum secreting cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta1 production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transforming growth factor beta1 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta2 production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transforming growth factor beta2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in odontogenesis of dentin-containing tooth IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in outflow tract septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pancreas development ISO
Inferred from Sequence Orthology
more info
 
involved_in pancreatic A cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pancreatic A cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 
involved_in positive regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle myoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardiac muscle myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardioblast differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cardioblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transforming growth factor beta activation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transforming growth factor beta activation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of antimicrobial humoral response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of antimicrobial humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estrogen IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to estrogen ISO
Inferred from Sequence Orthology
more info
 
involved_in response to growth factor ISO
Inferred from Sequence Orthology
more info
 
involved_in response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in sebaceous gland cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in sebaceous gland cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in sinoatrial node development ISO
Inferred from Sequence Orthology
more info
 
involved_in skin epidermis development IEA
Inferred from Electronic Annotation
more info
 
involved_in skin epidermis development ISO
Inferred from Sequence Orthology
more info
 
involved_in smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in tube morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in type B pancreatic cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within type B pancreatic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in type II pneumocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within type II pneumocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription factor GATA-6
Names
DNA-binding protein GATA-GT2
GATA-binding factor 6

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019185.2NP_062058.2  transcription factor GATA-6

    See identical proteins and their annotated locations for NP_062058.2

    Status: VALIDATED

    Source sequence(s)
    AI712574, JACYVU010000298, L22760
    UniProtKB/Swiss-Prot
    P46153
    Related
    ENSRNOP00000070439.2, ENSRNOT00000081399.2
    Conserved Domains (3) summary
    smart00401
    Location:435482
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:437488
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:147371
    GATA-N; GATA-type transcription activator, N-terminal

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051353.1 Reference mRatBN7.2 Primary Assembly

    Range
    2188121..2219532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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