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Ftl1 ferritin light chain 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29292, updated on 3-Jan-2019

Summary

Official Symbol
Ftl1provided by RGD
Official Full Name
ferritin light chain 1provided by RGD
Primary source
RGD:61813
See related
Ensembl:ENSRNOG00000020843
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ftl
Summary
iron-storage protein [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 7228.0), Spleen (RPKM 5625.8) and 9 other tissues See more
Orthologs

Genomic context

See Ftl1 in Genome Data Viewer
Location:
1q22
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101448190..101450034, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (102527136..102528980, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene RuvB-like AAA ATPase 2 Neighboring gene glycogen synthase 1 Neighboring gene BCL2 associated X, apoptosis regulator Neighboring gene dihydrodiol dehydrogenase Neighboring gene tubby-like protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Ferroptosis, organism-specific biosystem (from KEGG)
    Ferroptosis, organism-specific biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
  • Ferroptosis, conserved biosystem (from KEGG)
    Ferroptosis, conserved biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
  • Mineral absorption, organism-specific biosystem (from KEGG)
    Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
  • Mineral absorption, conserved biosystem (from KEGG)
    Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
  • NFE2L2, organism-specific biosystem (from WikiPathways)
    NFE2L2, organism-specific biosystem
    NFE2L2
  • Relationship between glutathione and NADPH, organism-specific biosystem (from WikiPathways)
    Relationship between glutathione and NADPH, organism-specific biosystem
    Relationship between glutathione and NADPH

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ferric iron binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT ferroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron ion binding ISO
Inferred from Sequence Orthology
more info
 
iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
cellular iron ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
intracellular sequestering of iron ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron ion transport IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to lead ion IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
autolysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autolysosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
intracellular ferritin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular ferritin complex ISO
Inferred from Sequence Orthology
more info
 
intracellular ferritin complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ferritin light chain 1
Names
ferritin L subunit 1
ferritin, light polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022500.4NP_071945.3  ferritin light chain 1

    See identical proteins and their annotated locations for NP_071945.3

    Status: PROVISIONAL

    Source sequence(s)
    BC061525
    UniProtKB/Swiss-Prot
    P02793
    Related
    ENSRNOP00000028315.4, ENSRNOT00000028315.6
    Conserved Domains (2) summary
    cd00904
    Location:10177
    Ferritin; Ferritin iron storage proteins
    pfam00210
    Location:14155
    Ferritin; Ferritin-like domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    101448190..101450034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    90192302..90194146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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