Gpi glucose-6-phosphate isomerase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpiprovided by RGD
Official Full Name: glucose-6-phosphate isomeraseprovided by RGD
Primary source: RGD:2727
See related: Ensembl:ENSRNOG00000023150 AllianceGenome:RGD:2727
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Amf; Nlk; Pgi; Phi; Gpi1
Summary: This gene encodes a member of the glucose phosphate isomerase protein family. A similar protein in human and mouse has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. [provided by RefSeq, Jan 2014]
Expression: Biased expression in Muscle (RPKM 2704.6), Heart (RPKM 1192.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (95965389..95996932, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (86828211..86856077, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (90063411..90091287, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuroleukin/Autocrine Motility Factor Receptor Pathway Promotes Proliferation of Articular Chondrocytes through Activation of AKT and Smad2/3
Title: Neuroleukin/Autocrine Motility Factor Receptor Pathway Promotes Proliferation of Articular Chondrocytes through Activation of AKT and Smad2/3.
Our results show that glucose-6-phosphate is not the only substrate of Glucose-6-Phosphate Isomerase.
Title: A new role of glucose-6-phosphate isomerase: protection of cell structures from malonic dialdehyde.
induces hyperpermeability of endothelial and mesothelial cells leading to accumulation of ascites fluid (Tumor Autocrine Motility Factor)
Title: Tumor autocrine motility factor induces hyperpermeability of endothelial and mesothelial cells leading to accumulation of ascites fluid.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gpi1 (e-PCR), detects polymorphism
- UniSTS:506947

PMC164521P1 (e-PCR)
- UniSTS:271494

Gpi1-s (e-PCR), detects polymorphism
- UniSTS:143242

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate derivative binding	IEA Inferred from Electronic Annotation more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables glucose-6-phosphate isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucose-6-phosphate isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose-6-phosphate isomerase activity	IEA Inferred from Electronic Annotation more info
enables glucose-6-phosphate isomerase activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables monosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables monosaccharide binding	IPI Inferred from Physical Interaction more info	PubMed
enables racemase and epimerase activity, acting on carbohydrates and derivatives	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in canonical glycolysis	IEA Inferred from Electronic Annotation more info
involved_in canonical glycolysis	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate derivative metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte homeostasis	ISO Inferred from Sequence Orthology more info
involved_in fructose 6-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fructose 6-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in glucose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose 6-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose 6-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucose 6-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycolytic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within mesoderm formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesoderm formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of glycolytic process through fructose-6-phosphate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of glycolytic process through fructose-6-phosphate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle stretch	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in ciliary membrane	IEA Inferred from Electronic Annotation more info
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glucose-6-phosphate isomerase

Names: autocrine motility factor

NP_997475.1

EC 5.3.1.9

XP_063139755.1

EC 5.3.1.9

XP_063139761.1

EC 5.3.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207592.1 → NP_997475.1 glucose-6-phosphate isomerase

See identical proteins and their annotated locations for NP_997475.1

Status: PROVISIONAL

Source sequence(s)

BC062005

UniProtKB/Swiss-Prot

Q6P6V0

UniProtKB/TrEMBL

A0A8I6A243

Related

ENSRNOP00000029515.3, ENSRNOT00000032613.6

Conserved Domains (1) summary

PRK00179
Location:1 → 554

pgi; glucose-6-phosphate isomerase; Reviewed

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

95965389..95996932 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283691.1 → XP_063139761.1 glucose-6-phosphate isomerase isoform X1

UniProtKB/Swiss-Prot

Q6P6V0

UniProtKB/TrEMBL

A0A8I6A243
XM_063283685.1 → XP_063139755.1 glucose-6-phosphate isomerase isoform X1

UniProtKB/Swiss-Prot

Q6P6V0

UniProtKB/TrEMBL

A0A8I6A243