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Map4k1 mitogen activated protein kinase kinase kinase kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292763, updated on 12-Aug-2018

Summary

Official Symbol
Map4k1provided by RGD
Official Full Name
mitogen activated protein kinase kinase kinase kinase 1provided by RGD
Primary source
RGD:1305463
See related
Ensembl:ENSRNOG00000020505
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hpk1
Expression
Biased expression in Spleen (RPKM 137.9), Thymus (RPKM 92.1) and 4 other tissues See more
Orthologs

Genomic context

See Map4k1 in Genome Data Viewer
Location:
1q21
Exon count:
32
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (87937126..87959514)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (89113867..89135540)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene zinc finger protein 420-like Neighboring gene zinc finger protein 569 Neighboring gene eukaryotic translation initiation factor 3, subunit K Neighboring gene ryanodine receptor 1 Neighboring gene RAS guanyl releasing protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
activation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
activation of MAPKKK activity IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
biological_process ND
No biological Data available
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cellular response to phorbol 13-acetate 12-myristate IEA
Inferred from Electronic Annotation
more info
 
cellular response to phorbol 13-acetate 12-myristate ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase kinase 1
Names
hematopoietic progenitor kinase 1
NP_001099713.1
XP_006228778.1
XP_008757344.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106243.1NP_001099713.1  mitogen-activated protein kinase kinase kinase kinase 1

    See identical proteins and their annotated locations for NP_001099713.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473979
    UniProtKB/TrEMBL
    D3Z8I4
    Related
    ENSRNOP00000027837.4, ENSRNOT00000027837.6
    Conserved Domains (3) summary
    smart00036
    Location:506813
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:17274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    87937126..87959514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228716.3XP_006228778.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform X1

    Conserved Domains (3) summary
    smart00036
    Location:506812
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:17274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  2. XM_008759122.2XP_008757344.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:17274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    cl02434
    Location:517767
    CNH; CNH domain

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    78661150..78682606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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