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Actc1 actin, alpha, cardiac muscle 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29275, updated on 24-Apr-2022

Summary

Official Symbol
Actc1provided by RGD
Official Full Name
actin, alpha, cardiac muscle 1provided by RGD
Primary source
RGD:2026
See related
Ensembl:ENSRNOG00000008536 AllianceGenome:RGD:2026
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity; microfilament motor activity; and myosin binding activity. Involved in cardiac muscle contraction; response to ethanol; and response to xenobiotic stimulus. Predicted to be located in several cellular components, including I band; filopodium; and lamellipodium. Predicted to be part of dynactin complex. Predicted to be active in actin filament; glutamatergic synapse; and sarcomere. Biomarker of hypertension. Human ortholog(s) of this gene implicated in atrial heart septal defect 5; dilated cardiomyopathy; dilated cardiomyopathy 1R; and hypertrophic cardiomyopathy 11. Orthologous to human ACTC1 (actin alpha cardiac muscle 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 34035.4) See more
Orthologs
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Genomic context

See Actc1 in Genome Data Viewer
Location:
3q35
Exon count:
7
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (100811987..100817523, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (105507403..105512939, complement)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101628 Neighboring gene gap junction protein, delta 2 Neighboring gene ribosomal protein L13, pseudogene 15 Neighboring gene uncharacterized LOC100910676 Neighboring gene aquarius intron-binding spliceosomal factor Neighboring gene zinc finger protein 770

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC156490

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
 
enables myosin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables myosin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin filament-based movement ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within actin-mediated cell contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in actin-myosin filament sliding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin-myosin filament sliding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within actomyosin structure organization ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac myofibril assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in heart contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heart contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in mesenchyme migration ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within skeletal muscle thin filament assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in I band ISO
Inferred from Sequence Orthology
more info
 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in filopodium ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in sarcomere IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
actin, alpha cardiac muscle 1
Names
actin, alpha, cardiac 1
alpha-actin cardiac
alpha-cardiac actin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019183.1NP_062056.1  actin, alpha cardiac muscle 1

    See identical proteins and their annotated locations for NP_062056.1

    Status: VALIDATED

    Source sequence(s)
    AI603593, AI706373, CF109672, CK356511
    UniProtKB/Swiss-Prot
    P68035
    Related
    ENSRNOP00000011773.3, ENSRNOT00000011773.5
    Conserved Domains (1) summary
    PTZ00281
    Location:4377
    PTZ00281; actin; Provisional

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    100811987..100817523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)