Mcpt1 mast cell protease 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mcpt1provided by RGD
Official Full Name: mast cell protease 1provided by RGD
Primary source: RGD:621058
See related: Ensembl:ENSRNOG00000020625 AllianceGenome:RGD:621058
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rMCP-1; rMCP-2; rMCP-I; rMCP-II
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Thymus (RPKM 21.9), Lung (RPKM 18.7) and 7 other tissues See more
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Genomic context

Location:: 15p12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (33841606..33844174)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (29871360..29873928)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (35032078..35034412)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phage display analysis showed that rMCP-2 is a chymase with a specificity similar to the corresponding enzyme in mice, mMCP-1, with a preference for Phe or Tyr in the P1 position, and a general preference for aliphatic amino acids both upstream and downstream of the cleavage site.
Title: rMCP-2, the Major Rat Mucosal Mast Cell Protease, an Analysis of Its Extended Cleavage Specificity and Its Potential Role in Regulating Intestinal Permeability by the Cleavage of Cell Adhesion and Junction Proteins.
These results show both an effective and relatively rapid model of FA assessed by means of specific antibody titres and the high production of RMCP-II and its intestinal gene expression
Title: Development and characterization of an effective food allergy model in Brown Norway rats.
Rapid expulsion of Trichinella spiralis first-stage larvae from rat intestine can occur in the absence of either intestinal mastocytosis or mast cell protease II release.
Title: Expulsion of secondary Trichinella spiralis infection in rats occurs independently of mucosal mast cell release of mast cell protease II.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mast cell protease 1

Names: group-specific protease; mast cell peptidase 1; mast cell peptidase 2; mast cell protease I; mast cell protease II

NP_742041.1

EC 3.4.21.39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172044.2 → NP_742041.1 mast cell protease 1 precursor

See identical proteins and their annotated locations for NP_742041.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

P00770

UniProtKB/TrEMBL

A6KH80

Related

ENSRNOP00000069470.1, ENSRNOT00000091757.3

Conserved Domains (2) summary

smart00020
Location:20 → 239

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:21 → 242

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...