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GRSF1 G-rich RNA sequence binding factor 1 [ Homo sapiens (human) ]

Gene ID: 2926, updated on 4-May-2020

Summary

Official Symbol
GRSF1provided by HGNC
Official Full Name
G-rich RNA sequence binding factor 1provided by HGNC
Primary source
HGNC:HGNC:4610
See related
Ensembl:ENSG00000132463 MIM:604851
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 14.1), brain (RPKM 13.8) and 25 other tissues See more
Orthologs

Genomic context

See GRSF1 in Genome Data Viewer
Location:
4q13.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (70815783..70843274, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71681499..71705627, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 784, pseudogene Neighboring gene RUN and FYVE domain containing 3 Neighboring gene RNA, U6 small nuclear 891, pseudogene Neighboring gene MOB kinase activator 1B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13125

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
mRNA polyadenylation TAS
Traceable Author Statement
more info
PubMed 
morphogenesis of embryonic epithelium IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitochondrial RNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098477.2NP_001091947.1  G-rich sequence factor 1 isoform 2

    See identical proteins and their annotated locations for NP_001091947.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC021989
    Consensus CDS
    CCDS47070.1
    UniProtKB/Swiss-Prot
    Q12849
    UniProtKB/TrEMBL
    A0A024RD99
    Conserved Domains (3) summary
    cd12505
    Location:87160
    RRM2_GRSF1; RNA recognition motif 2 in G-rich sequence factor 1 (GRSF-1) and similar proteins
    cd12733
    Location:239313
    RRM3_GRSF1; RNA recognition motif 3 in G-rich sequence factor 1 (GRSF-1) and similar proteins
    cl17169
    Location:165
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_002092.4NP_002083.4  G-rich sequence factor 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC021989
    Consensus CDS
    CCDS47069.1
    Related
    ENSP00000254799.6, ENST00000254799.11
    Conserved Domains (4) summary
    COG0724
    Location:307459
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12505
    Location:249322
    RRM2_GRSF1; RNA recognition motif 2 in G-rich sequence factor 1 (GRSF-1) and similar proteins
    cd12730
    Location:149227
    RRM1_GRSF1; RNA recognition motif 1 in G-rich sequence factor 1 (GRSF-1) and similar proteins
    cd12733
    Location:401475
    RRM3_GRSF1; RNA recognition motif 3 in G-rich sequence factor 1 (GRSF-1) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    70815783..70843274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531897.3XP_011530199.1  G-rich sequence factor 1 isoform X2

    See identical proteins and their annotated locations for XP_011530199.1

    UniProtKB/Swiss-Prot
    Q12849
    UniProtKB/TrEMBL
    A0A024RD99
    Related
    ENSP00000425430.1, ENST00000502323.5
    Conserved Domains (3) summary
    cd12505
    Location:87160
    RRM2_GRSF1; RNA recognition motif 2 in G-rich sequence factor 1 (GRSF-1) and similar proteins
    cd12733
    Location:239313
    RRM3_GRSF1; RNA recognition motif 3 in G-rich sequence factor 1 (GRSF-1) and similar proteins
    cl17169
    Location:165
    RRM_SF; RNA recognition motif (RRM) superfamily
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