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F2 coagulation factor II [ Rattus norvegicus (Norway rat) ]

Gene ID: 29251, updated on 18-Apr-2019

Summary

Official Symbol
F2provided by RGD
Official Full Name
coagulation factor IIprovided by RGD
Primary source
RGD:61996
See related
Ensembl:ENSRNOG00000016325
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
catalyzes the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptides A and B; involved in blood coagulation and wound repair [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 9803.3) See more
Orthologs

Genomic context

Location:
3q24
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (80529468..80542993, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (87228703..87242228, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein 4 Neighboring gene cytoskeleton associated protein 5 Neighboring gene low molecular weight phosphotyrosine protein phosphatase pseudogene Neighboring gene uncharacterized LOC103691846 Neighboring gene zinc finger protein 408 Neighboring gene Rho GTPase activating protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 
enzyme activator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
lipopolysaccharide binding IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
PubMed 
peptidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
thrombospondin receptor activity IEA
Inferred from Electronic Annotation
more info
 
thrombospondin receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
acute-phase response IEA
Inferred from Electronic Annotation
more info
 
antimicrobial humoral immune response mediated by antimicrobial peptide IEA
Inferred from Electronic Annotation
more info
 
antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
PubMed 
blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cytolysis by host of symbiont cells IEA
Inferred from Electronic Annotation
more info
 
cytolysis by host of symbiont cells ISO
Inferred from Sequence Orthology
more info
PubMed 
fibrinolysis IEA
Inferred from Electronic Annotation
more info
 
fibrinolysis ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of proteolysis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
PubMed 
neutrophil mediated killing of gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 
neutrophil mediated killing of gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
PubMed 
platelet activation IEA
Inferred from Electronic Annotation
more info
 
platelet activation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of collagen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of lipid kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lipid kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
response to Thyroglobulin triiodothyronine IEP
Inferred from Expression Pattern
more info
PubMed 
response to inactivity IEP
Inferred from Expression Pattern
more info
PubMed 
response to thyrotropin-releasing hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to thyroxine IEP
Inferred from Expression Pattern
more info
PubMed 
response to wounding ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
prothrombin
Names
coagulation factor 2
thrombin
NP_075213.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022924.2NP_075213.2  prothrombin precursor

    See identical proteins and their annotated locations for NP_075213.2

    Status: VALIDATED

    Source sequence(s)
    CO575133, DW391550, DW392486, DY318887, EX492416
    UniProtKB/TrEMBL
    G3V843
    Related
    ENSRNOP00000022233.3, ENSRNOT00000022233.5
    Conserved Domains (6) summary
    smart00020
    Location:359608
    Tryp_SPc; Trypsin-like serine protease
    smart00069
    Location:2589
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    smart00130
    Location:107189
    KR; Kringle domain
    cd00190
    Location:360612
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00051
    Location:215292
    Kringle; Kringle domain
    pfam09396
    Location:312359
    Thrombin_light; Thrombin light chain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    80529468..80542993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    76801000..76814280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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