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GRPR gastrin releasing peptide receptor [ Homo sapiens (human) ]

Gene ID: 2925, updated on 21-Dec-2019

Summary

Official Symbol
GRPRprovided by HGNC
Official Full Name
gastrin releasing peptide receptorprovided by HGNC
Primary source
HGNC:HGNC:4609
See related
Ensembl:ENSG00000126010 MIM:305670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BB2; BB2R
Summary
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in pancreas (RPKM 2.4), stomach (RPKM 0.7) and 3 other tissues See more
Orthologs

Genomic context

See GRPR in Genome Data Viewer
Location:
Xp22.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (16123565..16153518)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (16141424..16171641)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, U5F small nuclear 7, pseudogene Neighboring gene SET pseudogene 15 Neighboring gene MAGE family member B17 Neighboring gene ribosomal protein L6 pseudogene 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide binding IEA
Inferred from Electronic Annotation
more info
 
neuropeptide receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
learning or memory IEA
Inferred from Electronic Annotation
more info
 
motor behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
psychomotor behavior IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
response to external biotic stimulus IEA
Inferred from Electronic Annotation
more info
 
social behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
gastrin-releasing peptide receptor
Names
GRP-R
GRP-preferring bombesin receptor
bombesin receptor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012512.1 RefSeqGene

    Range
    5265..35218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005314.3NP_005305.1  gastrin-releasing peptide receptor

    See identical proteins and their annotated locations for NP_005305.1

    Status: REVIEWED

    Source sequence(s)
    AC078993, AU125660, M73481
    Consensus CDS
    CCDS14174.1
    UniProtKB/Swiss-Prot
    P30550
    UniProtKB/TrEMBL
    X5D7H2
    Related
    ENSP00000369643.2, ENST00000380289.3
    Conserved Domains (1) summary
    cd15124
    Location:41333
    7tmA_GRPR; gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    16123565..16153518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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