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Tbxt T-box transcription factor T [ Rattus norvegicus (Norway rat) ]

Gene ID: 292301, updated on 30-Sep-2021

Summary

Official Symbol
Tbxtprovided by RGD
Official Full Name
T-box transcription factor Tprovided by RGD
Primary source
RGD:1310141
See related
EnsemblRapid:ENSRNOG00000012229
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Lung (RPKM 9.3), Thymus (RPKM 6.6) and 4 other tissues See more
Orthologs
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Genomic context

See Tbxt in Genome Data Viewer
Location:
1q12
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (52298099..52309813, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (52887067..52900691, complement)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein LOC681210 Neighboring gene phosphodiesterase 10A Neighboring gene 60S ribosomal protein L23a-like Neighboring gene uncharacterized LOC120100103 Neighboring gene brachyury 2 Neighboring gene similar to Multifunctional protein ADE2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within anatomical structure morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bone morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within determination of heart left/right asymmetry ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic skeletal system development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesoderm development ISO
Inferred from Sequence Orthology
more info
 
involved_in mesoderm formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mesoderm migration involved in gastrulation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural plate morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within notochord development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within notochord formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within penetration of zona pellucida ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-anal tail morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within reproductive process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction involved in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in somitogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within somitogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-box transcription factor T
Names
T brachyury transcription factor
brachyury homolog
brachyury protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106209.1NP_001099679.1  T-box transcription factor T

    See identical proteins and their annotated locations for NP_001099679.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474059
    UniProtKB/TrEMBL
    D4A4W8
    Conserved Domains (1) summary
    cd20202
    Location:41219
    T-box_TBXT; DNA-binding domain of T-box transcription factor T and related T-box proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    52298099..52309813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103470.1XP_038959398.1  T-box transcription factor T isoform X2

    Conserved Domains (1) summary
    cd20202
    Location:41219
    T-box_TBXT; DNA-binding domain of T-box transcription factor T and related T-box proteins
  2. XM_017588873.2XP_017444362.1  T-box transcription factor T isoform X1

    Related
    ENSRNOP00000016471.3, ENSRNOT00000016471.4
    Conserved Domains (1) summary
    smart00425
    Location:42224
    TBOX; Domain first found in the mice T locus (Brachyury) protein
  3. XM_039103475.1XP_038959403.1  T-box transcription factor T isoform X3

    Related
    ENSRNOP00000092633.1, ENSRNOT00000110131.1
    Conserved Domains (1) summary
    cl00145
    Location:42178
    T-box; DNA-binding domain of the T-box transcription factor family
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