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Tbxt T-box transcription factor T [ Rattus norvegicus (Norway rat) ]

Gene ID: 292301, updated on 11-Jun-2025
Official Symbol
Tbxtprovided by RGD
Official Full Name
T-box transcription factor Tprovided by RGD
Primary source
RGD:1310141
See related
Ensembl:ENSRNOG00000012229 AllianceGenome:RGD:1310141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in cellular response to retinoic acid. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human TBXT (T-box transcription factor T). [provided by Alliance of Genome Resources, Jun 2025]
Expression
Biased expression in Lung (RPKM 9.3), Thymus (RPKM 6.6) and 4 other tissues See more
Orthologs
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See Tbxt in Genome Data Viewer
Location:
1q12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (54845674..54859340, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (52298104..52309813, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (52887067..52900691, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 10A Neighboring gene uncharacterized LOC134484996 Neighboring gene ribosomal protein L23a, pseudogene 4 Neighboring gene uncharacterized LOC120100103 Neighboring gene phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase, pseudogene 5 Neighboring gene brachyury 2

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within anatomical structure morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bone morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within bone morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle cell myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac muscle cell myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within determination of heart left/right asymmetry IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within determination of heart left/right asymmetry ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic skeletal system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic skeletal system development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesoderm development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mesoderm development ISO
Inferred from Sequence Orthology
more info
 
involved_in mesoderm formation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mesoderm migration involved in gastrulation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mesoderm migration involved in gastrulation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural plate morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural plate morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube closure IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within notochord development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within notochord development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within notochord formation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within notochord formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within penetration of zona pellucida IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within penetration of zona pellucida ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-anal tail morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within post-anal tail morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction involved in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within signal transduction involved in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in somitogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within somitogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within somitogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromatin IEA
Inferred from Electronic Annotation
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
T-box transcription factor T
Names
T brachyury transcription factor
brachyury homolog
brachyury protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106209.2NP_001099679.1  T-box transcription factor T

    See identical proteins and their annotated locations for NP_001099679.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KK19, A6KK20
    Conserved Domains (1) summary
    cd20202
    Location:41219
    T-box_TBXT; DNA-binding domain of T-box transcription factor T and related T-box proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    54845674..54859340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103475.2XP_038959403.1  T-box transcription factor T isoform X3

    UniProtKB/TrEMBL
    A0A8I6AEA5, A6KK20
    Related
    ENSRNOP00000092633.1, ENSRNOT00000110131.2
    Conserved Domains (1) summary
    cl00145
    Location:42178
    T-box; DNA-binding domain of the T-box transcription factor family
  2. XM_039103470.2XP_038959398.1  T-box transcription factor T isoform X2

    UniProtKB/TrEMBL
    A6KK19, A6KK20
    Conserved Domains (1) summary
    cd20202
    Location:41219
    T-box_TBXT; DNA-binding domain of T-box transcription factor T and related T-box proteins
  3. XM_017588873.3XP_017444362.1  T-box transcription factor T isoform X1

    UniProtKB/TrEMBL
    A6KK20, D4A4W8
    Related
    ENSRNOP00000016471.3, ENSRNOT00000016471.5
    Conserved Domains (1) summary
    smart00425
    Location:42224
    TBOX; Domain first found in the mice T locus (Brachyury) protein
  4. XM_063282870.1XP_063138940.1  T-box transcription factor T isoform X1

    UniProtKB/TrEMBL
    A6KK20, D4A4W8