Nox3 NADPH oxidase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nox3provided by RGD
Official Full Name: NADPH oxidase 3provided by RGD
Primary source: RGD:1303190
See related: Ensembl:ENSRNOG00000016490 AllianceGenome:RGD:1303190
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable heme binding activity and superoxide-generating NAD(P)H oxidase activity. Predicted to be involved in defense response and superoxide anion generation. Predicted to act upstream of or within detection of gravity; otolith development; and temperature homeostasis. Predicted to be located in cytoplasm. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Orthologous to human NOX3 (NADPH oxidase 3). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Brain (RPKM 2.4), Adrenal (RPKM 0.4) and 1 other tissue See more
Orthologs: all
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Genomic context

Location:: 1q11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (46643277..46708109, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (44238012..44302851, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (44550994..44615760, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggested that the high expression levels of NOX3 increased oxidative stress in stroke-prone hypertensive rat cerebrum.
Title: High Expression Levels of NADPH Oxidase 3 in the Cerebrum of Ten-Week-Old Stroke-Prone Spontaneously Hypertensive Rats.
NOX3 regulates stress-related genes in the cochlea, such as TRPV1 and KIM-1, and initiates apoptosis in the cochlea.
Title: Transtympanic administration of short interfering (si)RNA for the NOX3 isoform of NADPH oxidase protects against cisplatin-induced hearing loss in the rat.
These data provide a link between NOX3 and TRPV1 in cisplatin-induced hearing loss and suggest that targeting these proteins for knockdown by siRNA could serve as a novel approach in treating cisplatin ototoxicity.
Title: Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat.
NOX3 is a relevant source of ROS generation in the cochlear and vestibular systems and that NOX3-dependent ROS generation might contribute to hearing loss and balance problems in response to ototoxic drugs.
Title: NOX3, a superoxide-generating NADPH oxidase of the inner ear.

Submit: New GeneRIF Correction

General gene information

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Markers

Nox3 (e-PCR), detects polymorphism
- UniSTS:525523

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD(P)H oxidase H2O2-forming activity	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	TAS Traceable Author Statement more info	PubMed
enables superoxide-generating NAD(P)H oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide-generating NAD(P)H oxidase activity	IEA Inferred from Electronic Annotation more info
enables superoxide-generating NAD(P)H oxidase activity	ISO Inferred from Sequence Orthology more info
enables superoxide-generating NAD(P)H oxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables superoxide-generating NADPH oxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detection of gravity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within otolith development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to gravity	ISO Inferred from Sequence Orthology more info
involved_in superoxide anion generation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within superoxide anion generation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within temperature homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NADPH oxidase complex	IEA Inferred from Electronic Annotation more info
part_of NADPH oxidase complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: NADPH oxidase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004216.1 → NP_001004216.1 NADPH oxidase 3

See identical proteins and their annotated locations for NP_001004216.1

Status: PROVISIONAL

Source sequence(s)

AY573239

UniProtKB/Swiss-Prot

Q672K1

UniProtKB/TrEMBL

A0ABK0LFW3

Related

ENSRNOP00000022148.3, ENSRNOT00000022148.6

Conserved Domains (2) summary

cd06186
Location:295 → 568

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:66 → 217

Ferric_reduct; Ferric reductase like transmembrane component