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Epha3 Eph receptor A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29210, updated on 10-Oct-2019

Summary

Official Symbol
Epha3provided by RGD
Official Full Name
Eph receptor A3provided by RGD
Primary source
RGD:68389
See related
Ensembl:ENSRNOG00000030285
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
receptor tyrosine kinase; binds members of the ephrin-A family, ephrin-A2, -A3, -A4 and -A5 [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 29.7), Heart (RPKM 26.4) and 8 other tissues See more
Orthologs

Genomic context

See Epha3 in Genome Data Viewer
Location:
11p12
Exon count:
19
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (421253..783037, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (420518..782868, complement)

Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene nucleophosmin-like Neighboring gene casein kinase 2 subunit alpha' interacting protein Neighboring gene similar to ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GPI-linked ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
GPI-linked ephrin receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
GPI-linked ephrin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to follicle-stimulating hormone stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
PubMed 
endocardial cushion development ISO
Inferred from Sequence Orthology
more info
PubMed 
ephrin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
ephrin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
fasciculation of motor neuron axon ISO
Inferred from Sequence Orthology
more info
PubMed 
fasciculation of motor neuron axon ISS
Inferred from Sequence or Structural Similarity
more info
 
fasciculation of sensory neuron axon ISO
Inferred from Sequence Orthology
more info
PubMed 
fasciculation of sensory neuron axon ISS
Inferred from Sequence or Structural Similarity
more info
 
fever generation IEP
Inferred from Expression Pattern
more info
PubMed 
NOT motor neuron axon guidance ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
response to cytokine IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
synaptic membrane adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cellular_component ND
No biological Data available
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
presynapse ISO
Inferred from Sequence Orthology
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ephrin type-A receptor 3
Names
EK4
EPH-like kinase 4
rEK4
tyrosine-protein kinase TYRO4
tyrosine-protein kinase receptor REK4
NP_113752.1
XP_006248038.1
XP_006248039.1
XP_017453434.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031564.1NP_113752.1  ephrin type-A receptor 3 precursor

    See identical proteins and their annotated locations for NP_113752.1

    Status: PROVISIONAL

    Source sequence(s)
    U69278
    UniProtKB/Swiss-Prot
    O08680
    Related
    ENSRNOP00000043263.2, ENSRNOT00000040065.2
    Conserved Domains (8) summary
    cd09544
    Location:913975
    SAM_EPH-A3; SAM domain of EPH-A3 subfamily of tyrosine kinase receptors
    smart00454
    Location:909976
    SAM; Sterile alpha motif
    cd10481
    Location:29201
    EphR_LBD_A3; Ligand Binding Domain of Ephrin type-A Receptor 3
    cd00063
    Location:437526
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:617883
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:327417
    fn3; Fibronectin type III domain
    pfam07714
    Location:622879
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:566617
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

    Range
    421253..783037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247976.3XP_006248038.1  ephrin type-A receptor 3 isoform X1

    Conserved Domains (8) summary
    cd09544
    Location:912974
    SAM_EPH-A3; SAM domain of EPH-A3 subfamily of tyrosine kinase receptors
    smart00454
    Location:908975
    SAM; Sterile alpha motif
    cd10481
    Location:29201
    EphR_LBD_A3; Ligand Binding Domain of Ephrin type-A Receptor 3
    cd00063
    Location:437527
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:616882
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:327417
    fn3; Fibronectin type III domain
    pfam07714
    Location:621878
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:565616
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  2. XM_006247977.3XP_006248039.1  ephrin type-A receptor 3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JT71
    Related
    ENSRNOP00000068593.1, ENSRNOT00000090197.1
    Conserved Domains (8) summary
    cd09544
    Location:910972
    SAM_EPH-A3; SAM domain of EPH-A3 subfamily of tyrosine kinase receptors
    smart00454
    Location:906973
    SAM; Sterile alpha motif
    cd10481
    Location:27198
    EphR_LBD_A3; Ligand Binding Domain of Ephrin type-A Receptor 3
    cd00063
    Location:434525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:614880
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:324414
    fn3; Fibronectin type III domain
    pfam07714
    Location:619876
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:563614
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  3. XM_017597945.1XP_017453434.1  ephrin type-A receptor 3 isoform X3

    Conserved Domains (8) summary
    cd09544
    Location:863925
    SAM_EPH-A3; SAM domain of EPH-A3 subfamily of tyrosine kinase receptors
    smart00454
    Location:859926
    SAM; Sterile alpha motif
    cd00063
    Location:387478
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:567833
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:277367
    fn3; Fibronectin type III domain
    pfam07714
    Location:572829
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:516567
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:2151
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

Alternate Rn_Celera

Genomic

  1. AC_000079.1 Alternate Rn_Celera

    Range
    1134161..1466533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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