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CXCL3 C-X-C motif chemokine ligand 3 [ Homo sapiens (human) ]

Gene ID: 2921, updated on 27-Nov-2024

Summary

Official Symbol
CXCL3provided by HGNC
Official Full Name
C-X-C motif chemokine ligand 3provided by HGNC
Primary source
HGNC:HGNC:4604
See related
Ensembl:ENSG00000163734 MIM:139111; AllianceGenome:HGNC:4604
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b
Summary
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Biased expression in appendix (RPKM 8.6), bone marrow (RPKM 6.3) and 12 other tissues See more
Orthologs
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Genomic context

See CXCL3 in Genome Data Viewer
Location:
4q13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (74036589..74038689, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (77380195..77382297, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (74902306..74904406, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900715 Neighboring gene C-X-C motif chemokine ligand 5 Neighboring gene RNA, 7SL, cytoplasmic 218, pseudogene Neighboring gene uncharacterized LOC105377275 Neighboring gene pro-platelet basic protein pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of chemokine (C-X-C motif) ligand 3 (CXCL3) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chemokine activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
C-X-C motif chemokine 3
Names
GRO-gamma
GRO-gamma(1-73)
GRO3 oncogene
MGSA gamma
MIP2-beta
chemokine (C-X-C motif) ligand 3
growth-regulated protein gamma
macrophage inflammatory protein 2-beta
melanoma growth stimulatory activity gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002090.3NP_002081.2  C-X-C motif chemokine 3 precursor

    See identical proteins and their annotated locations for NP_002081.2

    Status: REVIEWED

    Source sequence(s)
    AW079760, BC065743
    Consensus CDS
    CCDS34007.1
    UniProtKB/Swiss-Prot
    P19876, Q4W5H9
    Related
    ENSP00000296026.4, ENST00000296026.4
    Conserved Domains (1) summary
    cd00273
    Location:40102
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    74036589..74038689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    77380195..77382297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)