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CXCL3 C-X-C motif chemokine ligand 3 [ Homo sapiens (human) ]

Gene ID: 2921, updated on 21-Dec-2019

Summary

Official Symbol
CXCL3provided by HGNC
Official Full Name
C-X-C motif chemokine ligand 3provided by HGNC
Primary source
HGNC:HGNC:4604
See related
Ensembl:ENSG00000163734 MIM:139111
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b
Summary
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
Expression
Biased expression in appendix (RPKM 8.6), bone marrow (RPKM 6.3) and 12 other tissues See more
Orthologs

Genomic context

See CXCL3 in Genome Data Viewer
Location:
4q13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (74036589..74038689, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (74902306..74904490, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine ligand 5 Neighboring gene RNA, 7SL, cytoplasmic 218, pseudogene Neighboring gene uncharacterized LOC105377275 Neighboring gene pro-platelet basic protein pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of chemokine (C-X-C motif) ligand 3 (CXCL3) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
C-X-C motif chemokine 3
Names
GRO-gamma
GRO-gamma(1-73)
GRO3 oncogene
MGSA gamma
MIP2-beta
chemokine (C-X-C motif) ligand 3
growth-regulated protein gamma
macrophage inflammatory protein 2-beta
melanoma growth stimulatory activity gamma

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002090.3NP_002081.2  C-X-C motif chemokine 3 precursor

    See identical proteins and their annotated locations for NP_002081.2

    Status: REVIEWED

    Source sequence(s)
    AW079760, BC065743
    Consensus CDS
    CCDS34007.1
    UniProtKB/Swiss-Prot
    P19876
    Related
    ENSP00000296026.4, ENST00000296026.4
    Conserved Domains (1) summary
    cd00273
    Location:40102
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    74036589..74038689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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