Ctf1 cardiotrophin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctf1provided by RGD
Official Full Name: cardiotrophin 1provided by RGD
Primary source: RGD:2442
See related: EnsemblRapid:ENSRNOG00000018962 AllianceGenome:RGD:2442
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables cytokine activity and leukemia inhibitory factor receptor binding activity. Involved in leukemia inhibitory factor signaling pathway and nervous system development. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Biomarker of hypertension and hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CTF1 (cardiotrophin 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Kidney (RPKM 22.5), Muscle (RPKM 16.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (191758512..191771259)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (182328035..182336346)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (199162319..199168296)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the chronic kidney disease-cardiac hypertrophy model exercise rescues cardiac disease via cardiotrophin-1/LIFR/gp 130/JAK/STAT3 pathway.
Title: Exercise rescued chronic kidney disease by attenuating cardiac hypertrophy through the cardiotrophin-1 -> LIFR/gp 130 -> JAK/STAT3 pathway.
Cardiotrophin-1 modulates glucose transport in cardiomyocytes positively or negatively depending on its concentration.
Title: Dual effect of the heart-targeting cytokine cardiotrophin-1 on glucose transport in cardiomyocytes.
Cardiomyocytes treated with CT-1 present high spontaneous Ca(2+) release during diastole, a mechanism linked to arrhythmogenicity in the pathologic heart.
Title: Cardiotrophin-1 induces sarcoplasmic reticulum Ca(2+) leak and arrhythmogenesis in adult rat ventricular myocytes.
Cardiotrophin 1 is involved in cardiac, vascular, and renal fibrosis and dysfunction.
Title: Cardiotrophin 1 is involved in cardiac, vascular, and renal fibrosis and dysfunction.
Data suggest a key role for CT-1 in cardiac remodeling induced by aldosterone independent of changes in blood pressure levels.
Title: A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone.
IGF1, CT1, and GDNF have partially overlapping but not identical effects on extraocular muscle contractile properties
Title: How to make rapid eye movements "rapid": the role of growth factors for muscle contractile properties.
CT-1 induces VSMCs proliferation, hypertrophy and extracellular matrix production, and is upregulated in hypertension and by aldosterone. CT-1 may represent a new target of vascular wall remodeling in hypertension
Title: Vascular effects of cardiotrophin-1: a role in hypertension?
CT-1 can affect the expression of GATA4 mRNA and the binding activity of cardiac myocytes
Title: Relation of Cardiotrophin-1 (CT-1) and cardiac transcription factor GATA4 expression in rat's cardiac myocytes hypertrophy and apoptosis.
Motoneurons retrogradely transport from the tongue radiolabeled GDNF, BDNF, and cardiotrophin-1; cardiotrophin-1 follows a strict degradation pathway after retrograde transport to the soma.
Title: Synaptic targeting of retrogradely transported trophic factors in motoneurons: comparison of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor, and cardiotrophin-1 with tetanus toxin.
Ctf1 has a possible role in post-MI wound healing
Title: Cardiotrophin-1: expression in experimental myocardial infarction and potential role in post-MI wound healing.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cytokine activity	TAS Traceable Author Statement more info	PubMed
enables leukemia inhibitory factor receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in leukemia inhibitory factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cardiotrophin-1

Names: CT-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.