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Ctf1 cardiotrophin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29201, updated on 21-Jul-2018

Summary

Official Symbol
Ctf1provided by RGD
Official Full Name
cardiotrophin 1provided by RGD
Primary source
RGD:2442
See related
Ensembl:ENSRNOG00000018962
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Interleukin-6 family cytokine with hypertrophic and protective effects in cardiac cells; also a neurotrophic factor [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 22.5), Muscle (RPKM 16.7) and 9 other tissues See more
Orthologs

Genomic context

See Ctf1 in Genome Data Viewer
Location:
1q37
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199162319..199168296)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (206186511..206191930)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene ring finger protein 40 Neighboring gene zinc finger protein 629 Neighboring gene BCL tumor suppressor 7C Neighboring gene microRNA 762 Neighboring gene cardiotrophin 2 Neighboring gene uncharacterized LOC102554987

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine activity TAS
Traceable Author Statement
more info
PubMed 
leukemia inhibitory factor receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
leukemia inhibitory factor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IDA
Inferred from Direct Assay
more info
PubMed 
neuron development IEA
Inferred from Electronic Annotation
more info
 
neuron development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017129.1NP_058825.1  cardiotrophin-1

    See identical proteins and their annotated locations for NP_058825.1

    Status: PROVISIONAL

    Source sequence(s)
    D78591
    UniProtKB/Swiss-Prot
    Q63086
    Related
    ENSRNOP00000025646.1, ENSRNOT00000025646.2
    Conserved Domains (1) summary
    cl21565
    Location:29194
    LIF_OSM; LIF / OSM family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    199162319..199168296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230221.3XP_006230283.1  cardiotrophin-1 isoform X1

    Conserved Domains (1) summary
    cl21565
    Location:28193
    LIF_OSM; LIF / OSM family
  2. XM_017588854.1XP_017444343.1  cardiotrophin-1 isoform X2

    Conserved Domains (1) summary
    cl21565
    Location:22187
    LIF_OSM; LIF / OSM family
  3. XM_017588855.1XP_017444344.1  cardiotrophin-1 isoform X3

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    179979246..179984456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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