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Dus2 dihydrouridine synthase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291978, updated on 2-Oct-2018

Summary

Official Symbol
Dus2provided by RGD
Official Full Name
dihydrouridine synthase 2provided by RGD
Primary source
RGD:1305612
See related
Ensembl:ENSRNOG00000019819
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dus2l; RGD1305612
Expression
Biased expression in Spleen (RPKM 53.6), Adrenal (RPKM 38.0) and 9 other tissues See more
Orthologs

Genomic context

See Dus2 in Genome Data Viewer
Location:
19q12
Exon count:
17
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37990374..38033590)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (48857360..48900338)

Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene dipeptidase 2 Neighboring gene DEAD-box helicase 28 Neighboring gene nuclear factor of activated T-cells 3 Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene phospholipase A2, group XV

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 
double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
tRNA dihydrouridine synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of cell death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
tRNA dihydrouridine synthesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
NP_001099651.1
XP_017456720.1
XP_017456721.1
XP_017456722.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106181.1NP_001099651.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

    See identical proteins and their annotated locations for NP_001099651.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/TrEMBL
    B0BN89
    Related
    ENSRNOP00000026827.5, ENSRNOT00000026827.5
    Conserved Domains (3) summary
    COG0042
    Location:10314
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd00048
    Location:369433
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd02801
    Location:13252
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

    Range
    37990374..38033590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601232.1XP_017456721.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X2

  2. XM_017601231.1XP_017456720.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1

    UniProtKB/TrEMBL
    B0BN89
    Conserved Domains (3) summary
    COG0042
    Location:10314
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd00048
    Location:369433
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd02801
    Location:13252
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
  3. XM_017601233.1XP_017456722.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X3

    Conserved Domains (3) summary
    COG0042
    Location:1201
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    cd00048
    Location:256320
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd02801
    Location:1139
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

Alternate Rn_Celera

Genomic

  1. AC_000087.1 Alternate Rn_Celera

    Range
    33339293..33382226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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