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Ces4a carboxylesterase 4A [ Rattus norvegicus (Norway rat) ]

Gene ID: 291955, updated on 8-Apr-2026
Official Symbol
Ces4aprovided by RGD
Official Full Name
carboxylesterase 4Aprovided by RGD
Primary source
RGD:1307418
See related
Ensembl:ENSRNOG00000014257 AllianceGenome:RGD:1307418
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ces8; RGD1307418
Summary
Predicted to enable carboxylic ester hydrolase activity. Orthologous to human CES4A (carboxylesterase 4A). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Liver (RPKM 25.1), Testes (RPKM 18.6) and 1 other tissue See more
Orthologs
all
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See Ces4a in Genome Data Viewer
Location:
19q11
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (49921643..49942838)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33011731..33030119)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37090018..37111448)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene carboxylesterase 2H Neighboring gene carboxylesterase 3a Neighboring gene small nucleolar RNA SNORA17 Neighboring gene U6 spliceosomal RNA

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carboxylesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
carboxylesterase 4A
Names
carboxylesterase 8 (putative)
NP_001099646.1
XP_038953520.1
XP_038953521.1
XP_038953522.1
XP_038953523.1
XP_038953524.1
XP_038953525.1
XP_038953526.1
XP_038953527.1
XP_063133971.1
XP_063133972.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106176.1 → NP_001099646.1  carboxylesterase 4A precursor

    See identical proteins and their annotated locations for NP_001099646.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/TrEMBL
    A6IYL9, D4AE76
    Related
    ENSRNOP00000019169.2, ENSRNOT00000019169.5
    Conserved Domains (1) summary
    pfam00135
    Location:33 → 554
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    49921643..49942838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277901.1 → XP_063133971.1  carboxylesterase 4A isoform X1

  2. XM_039097599.2 → XP_038953527.1  carboxylesterase 4A isoform X4

    Conserved Domains (1) summary
    pfam00135
    Location:15 → 449
    COesterase; Carboxylesterase family

  3. XM_039097596.2 → XP_038953524.1  carboxylesterase 4A isoform X4

    Conserved Domains (1) summary
    pfam00135
    Location:15 → 449
    COesterase; Carboxylesterase family

  4. XM_063277902.1 → XP_063133972.1  carboxylesterase 4A isoform X3

  5. XM_039097593.2 → XP_038953521.1  carboxylesterase 4A isoform X4

    Conserved Domains (1) summary
    pfam00135
    Location:15 → 449
    COesterase; Carboxylesterase family

  6. XM_039097598.2 → XP_038953526.1  carboxylesterase 4A isoform X4

    Conserved Domains (1) summary
    pfam00135
    Location:15 → 449
    COesterase; Carboxylesterase family

  7. XM_039097594.2 → XP_038953522.1  carboxylesterase 4A isoform X4

    Conserved Domains (1) summary
    pfam00135
    Location:15 → 449
    COesterase; Carboxylesterase family

  8. XM_039097597.2 → XP_038953525.1  carboxylesterase 4A isoform X4

    Conserved Domains (1) summary
    pfam00135
    Location:15 → 449
    COesterase; Carboxylesterase family

  9. XM_039097595.2 → XP_038953523.1  carboxylesterase 4A isoform X4

    Conserved Domains (1) summary
    pfam00135
    Location:15 → 449
    COesterase; Carboxylesterase family

  10. XM_039097592.2 → XP_038953520.1  carboxylesterase 4A isoform X2

    Conserved Domains (1) summary
    pfam00135
    Location:10 → 531
    COesterase; Carboxylesterase family
Nucleotide Protein Strain
Heading Accession and Version

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