Orc6 origin recognition complex, subunit 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Orc6provided by RGD
Official Full Name: origin recognition complex, subunit 6provided by RGD
Primary source: RGD:1311437
See related: Ensembl:ENSRNOG00000024043 AllianceGenome:RGD:1311437
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Orc6l
Summary: Predicted to enable DNA binding activity. Predicted to be involved in DNA replication initiation. Predicted to act upstream of or within DNA-templated DNA replication. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 3. Orthologous to human ORC6 (origin recognition complex subunit 6). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Thymus (RPKM 68.5), Spleen (RPKM 59.2) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 19q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (37931085..37938856, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (21757867..21765638, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (27457541..27464804, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication initiation	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	ISO Inferred from Sequence Orthology more info
involved_in DNA-templated DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA-templated DNA replication	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
part_of nuclear origin of replication recognition complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear origin of replication recognition complex	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of origin recognition complex	IEA Inferred from Electronic Annotation more info
part_of origin recognition complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: origin recognition complex subunit 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033690.1 → NP_001028862.1 origin recognition complex subunit 6

See identical proteins and their annotated locations for NP_001028862.1

Status: PROVISIONAL

Source sequence(s)

BC101871

UniProtKB/TrEMBL

F7FAH8, Q3T1K3

Related

ENSRNOP00000035958.6, ENSRNOT00000039467.7

Conserved Domains (3) summary

cd11583
Location:94 → 186

Orc6_mid; Middle domain of the origin recognition complex subunit 6

pfam05460
Location:9 → 94

ORC6; Origin recognition complex subunit 6 (ORC6)

cd16075
Location:210 → 259

ORC6_CTD; C-terminal domain of the eukaryotic origin recognition complex subunit ORC6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

37931085..37938856 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277872.1 → XP_063133942.1 origin recognition complex subunit 6 isoform X1
XM_063277873.1 → XP_063133943.1 origin recognition complex subunit 6 isoform X2

UniProtKB/TrEMBL

A6KDE7