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Areg amphiregulin [ Rattus norvegicus (Norway rat) ]

Gene ID: 29183, updated on 18-Sep-2018

Summary

Official Symbol
Aregprovided by RGD
Official Full Name
amphiregulinprovided by RGD
Primary source
RGD:2149
See related
Ensembl:ENSRNOG00000002754
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
may act as a growth factor during central nervous system development [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 20.5), Lung (RPKM 3.7) and 1 other tissue See more
Orthologs

Genomic context

See Areg in Genome Data Viewer
Location:
14p22
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (18521921..18531179, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (18431477..18440735, complement)

Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene prostate androgen-regulated mucin-like protein 1 Neighboring gene betacellulin Neighboring gene epiregulin Neighboring gene epithelial mitogen

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epidermal growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
central nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis ISO
Inferred from Sequence Orthology
more info
 
epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
epithelial cell proliferation involved in mammary gland duct elongation IEA
Inferred from Electronic Annotation
more info
 
epithelial cell proliferation involved in mammary gland duct elongation ISO
Inferred from Sequence Orthology
more info
 
glial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
mammary gland alveolus development IEA
Inferred from Electronic Annotation
more info
 
mammary gland alveolus development ISO
Inferred from Sequence Orthology
more info
 
mammary gland branching involved in thelarche IEA
Inferred from Electronic Annotation
more info
 
mammary gland branching involved in thelarche ISO
Inferred from Sequence Orthology
more info
 
negative regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to estradiol ISO
Inferred from Sequence Orthology
more info
 
response to glucocorticoid IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
amphiregulin
Names
AR
SDGF
schwannoma-derived growth factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017123.1NP_058819.1  amphiregulin preproprotein

    See identical proteins and their annotated locations for NP_058819.1

    Status: PROVISIONAL

    Source sequence(s)
    X55183
    UniProtKB/Swiss-Prot
    P24338
    Related
    ENSRNOP00000003703.2, ENSRNOT00000003703.4
    Conserved Domains (1) summary
    PHA02887
    Location:137177
    PHA02887; EGF-like protein; Provisional

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

    Range
    18521921..18531179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000082.1 Alternate Rn_Celera

    Range
    16350045..16359315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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