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Car7 carbonic anhydrase 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291819, updated on 5-Mar-2024

Summary

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Official Symbol
Car7provided by RGD
Official Full Name
carbonic anhydrase 7provided by RGD
Primary source
RGD:1306842
See related
Ensembl:ENSRNOG00000012371 AllianceGenome:RGD:1306842
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ca7
Summary
Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process and regulation of intracellular pH. Predicted to act upstream of or within positive regulation of GABAergic synaptic transmission; positive regulation of cellular pH reduction; and regulation of chloride transport. Predicted to be located in cytosol. Orthologous to human CA7 (carbonic anhydrase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 42.6), Kidney (RPKM 40.0) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19p14
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (435520..444927, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (429063..438478, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (636545..645935, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483518 Neighboring gene pyruvate dehydrogenase phosphatase catalytic subunit 2 Neighboring gene NEDD8 activating enzyme E1 subunit 1 Neighboring gene U6 spliceosomal RNA Neighboring gene telomere repeat binding bouquet formation protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Carbonic anhydrase isoform VII acts as a molecular switch in the development of synchronous gamma-frequency firing of hippocampal CA1 pyramidal cells. Ruusuvuori E, et al. J Neurosci, 2004 Mar 17. PMID 15028762, Free PMC Article
  2. Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. Ruusuvuori E, et al. EMBO J, 2013 Aug 14. PMID 23881097, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbonate dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cellular pH reduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of chloride transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
carbonic anhydrase 7
Names
carbonic anhydrase VII
NP_001099635.1
XP_006255113.1
XP_008770465.1
XP_063133905.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106165.1 → NP_001099635.1  carbonic anhydrase 7

    See identical proteins and their annotated locations for NP_001099635.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474006
    UniProtKB/TrEMBL
    A0A8I6AD38, A6JXV1, B2RZ61, F7FEQ2
    Related
    ENSRNOP00000016521.5, ENSRNOT00000016521.8
    Conserved Domains (1) summary
    cd03149
    Location:27 → 262
    alpha_CA_VII; Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    435520..444927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772243.4 → XP_008770465.1  carbonic anhydrase 7 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AD38
    Conserved Domains (1) summary
    cl00012
    Location:27 → 230
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  2. XM_063277835.1 → XP_063133905.1  carbonic anhydrase 7 isoform X3

  3. XM_006255051.5 → XP_006255113.1  carbonic anhydrase 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AD38
    Conserved Domains (1) summary
    cl00012
    Location:1 → 206
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
Nucleotide Protein Strain
Heading Accession and Version

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