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GRM7 glutamate metabotropic receptor 7 [ Homo sapiens (human) ]

Gene ID: 2917, updated on 19-Sep-2021

Summary

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Official Symbol
GRM7provided by HGNC
Official Full Name
glutamate metabotropic receptor 7provided by HGNC
Primary source
HGNC:HGNC:4599
See related
Ensembl:ENSG00000196277 MIM:604101
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUR7; MGLU7; GPRC1G; MGLUR7; NEDSHBA; PPP1R87
Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See GRM7 in Genome Data Viewer
Location:
3p26.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (6861115..7743038)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (6902802..7783220)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene GRM7 antisense RNA 3 Neighboring gene uncharacterized LOC105376943 Neighboring gene uncharacterized LOC105376945 Neighboring gene GRM7 antisense RNA 2 Neighboring gene GRM7 antisense RNA 1 Neighboring gene uncharacterized LOC101927394 Neighboring gene LMCD1 antisense RNA 1 Neighboring gene uncharacterized LOC107986010 Neighboring gene RNA, U4atac small nuclear 17, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A large consanguineous family with a homozygous Metabotropic Glutamate Receptor 7 (mGlu7) variant and developmental epileptic encephalopathy: Effect on protein structure and ligand affinity. Jdila MB, et al. Orphanet J Rare Dis, 2021 Jul 17. PMID 34273994, Free PMC Article
  2. A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes. Fisher NM, et al. JCI Insight, 2021 Feb 22. PMID 33476302, Free PMC Article
  3. Biallelic GRM7 variants cause epilepsy, microcephaly, and cerebral atrophy. Marafi D, et al. Ann Clin Transl Neurol, 2020 May. PMID 32286009, Free PMC Article
  4. Variants of GRM7 as risk factor and response to antipsychotic therapy in schizophrenia. Liang W, et al. Transl Psychiatry, 2020 Mar 3. PMID 32127521, Free PMC Article
  5. GRM7 polymorphisms are not associated with ischemic stroke in Iranian population. Safari MR, et al. Nucleosides Nucleotides Nucleic Acids, 2020. PMID 32011203

See all (79) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A large consanguineous family with a homozygous Metabotropic Glutamate Receptor 7 (mGlu7) variant and developmental epileptic encephalopathy: Effect on protein structure and ligand affinity.
    Title: A large consanguineous family with a homozygous Metabotropic Glutamate Receptor 7 (mGlu7) variant and developmental epileptic encephalopathy: Effect on protein structure and ligand affinity.
  2. Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.
    Title: Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.
  3. Variants of GRM7 as risk factor and response to antipsychotic therapy in schizophrenia.
    Title: Variants of GRM7 as risk factor and response to antipsychotic therapy in schizophrenia.
  4. Biallelic GRM7 variants cause epilepsy, microcephaly, and cerebral atrophy.
    Title: Biallelic GRM7 variants cause epilepsy, microcephaly, and cerebral atrophy.
  5. GRM7 polymorphisms are not associated with ischemic stroke in Iranian population.
    Title: <i>GRM7</i> polymorphisms are not associated with ischemic stroke in Iranian population.
  6. frequency of A allele of the rs779867 OF grm7 was significantly lower in the schizophrenic patients compared with healthy subjects (OR (95% CI) = 0.71 (0.56-0.89), adjusted P value = 0.008)
    Title: GRM7 polymorphisms and risk of schizophrenia in Iranian population.
  7. There were no significant differences in genotype, allele and haplotypes frequencies of the GRM7 rs6782011 and rs779867 between bipolar disorder 1 (BPD1) patients and controls. The CC genotype of the rs6782011 was significantly associated with BPD2 in a recessive model and with ADHD in dominant and co-dominant models.The C G haplotype was more prevalent among both BPD2 patients and MDD patients.
    Title: Glutamate receptor metabotropic 7 (GRM7) gene polymorphisms in mood disorders and attention deficit hyperactive disorder.
  8. revealed significant interethnic differences in allele polymorphisms of NAT2, GRM7 and GRHL2 exhibit quite marked ethnic differences in Roma populations
    Title: Age-Related Hearing Impairment Associated NAT2, GRM7, GRHL2 Susceptibility Gene Polymorphisms and Haplotypes in Roma and Hungarian Populations.
  9. These findings provide a model in which Nedd4 and beta-arrestin act together as a complex to regulate mGlu7 surface expression and function at presynaptic terminals.
    Title: Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor.
  10. The present study showed that the genetic polymorphisms of GRM7 are associated with susceptibility to Age-related Hearing Impairment. The SNP rs9880404 was found to be associated with increased risk for ARHI in a dominant pattern. SNPs rs11928865, rs1353828, and rs9814809 were found not to be associated with susceptibility to ARHI .
    Title: The Association of GRM7 Single Nucleotide Polymorphisms with Age-Related Hearing Impairment in a Taiwanese Population.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
A genome-wide scan for breast cancer risk haplotypes among African American women.
GeneReviews: Not available
Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts.
GeneReviews: Not available
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
GeneReviews: Not available
Genome-wide association study of panic disorder in the Japanese population.
GeneReviews: Not available
Genome-wide association study of personality traits in bipolar patients.
GeneReviews: Not available
Neurodevelopmental disorder with seizures, hypotonia, and brain imaging abnormalities
MedGen: C5394517 OMIM: 618922 GeneReviews: Not available
Compare labs
Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of GRM7 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ40498

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables adenylate cyclase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables group III metabotropic glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables group III metabotropic glutamate receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein dimerization activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables serine binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in axon development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in behavioral fear response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of glutamate secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cyclase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in asymmetric synapse ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendritic shaft ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in integral component of plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in presynaptic active zone ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
metabotropic glutamate receptor 7
Names
glutamate receptor, metabotropic 7
protein phosphatase 1, regulatory subunit 87

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029781.1 RefSeqGene

    Range
    5001..885419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000844.4 → NP_000835.1  metabotropic glutamate receptor 7 isoform a precursor

    See identical proteins and their annotated locations for NP_000835.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as hmGluR7a) encodes the predominant isoform (a).
    Source sequence(s)
    AB209214, AC077690, AK123326, AK312488, X94552
    Consensus CDS
    CCDS43042.1
    UniProtKB/Swiss-Prot
    Q14831
    UniProtKB/TrEMBL
    B2R693, Q59G95
    Related
    ENSP00000350348.4, ENST00000357716.9
    Conserved Domains (4) summary
    cd06376
    Location:47 → 511
    PBP1_mGluR_groupIII; Ligand-binding domain of the group III metabotropic glutamate receptor
    pfam00003
    Location:602 → 847
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:77 → 484
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:521 → 567
    NCD3G; Nine Cysteines Domain of family 3 GPCR

  2. NM_181874.3 → NP_870989.1  metabotropic glutamate receptor 7 isoform b precursor

    See identical proteins and their annotated locations for NP_870989.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as hmGluR7b) differs in the 3' UTR and includes an alternate segment in the 3' coding region, compared to variant 1, which results in a frameshift. The encoded isoform (b) has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC077690, AK123326, AK312488, BC136459, X94552
    UniProtKB/Swiss-Prot
    Q14831
    UniProtKB/TrEMBL
    B2R693, B9EGG9
    Related
    ENSP00000417536.1, ENST00000486284.5
    Conserved Domains (4) summary
    cd06376
    Location:47 → 511
    PBP1_mGluR_groupIII; Ligand-binding domain of the group III metabotropic glutamate receptor
    pfam00003
    Location:602 → 847
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:77 → 484
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:521 → 567
    NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    6861115..7743038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006272.1 → XP_016861761.1  metabotropic glutamate receptor 7 isoform X1

    Related
    ENSP00000384585.4, ENST00000402647.6

  2. XM_017006273.1 → XP_016861762.1  metabotropic glutamate receptor 7 isoform X2

  3. XM_024453495.1 → XP_024309263.1  metabotropic glutamate receptor 7 isoform X3

    Conserved Domains (3) summary
    pfam07562
    Location:104 → 152
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15451
    Location:172 → 478
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1 → 94
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  4. XM_024453492.1 → XP_024309260.1  metabotropic glutamate receptor 7 isoform X3

    Conserved Domains (3) summary
    pfam07562
    Location:104 → 152
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15451
    Location:172 → 478
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1 → 94
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  5. XM_024453494.1 → XP_024309262.1  metabotropic glutamate receptor 7 isoform X3

    Conserved Domains (3) summary
    pfam07562
    Location:104 → 152
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15451
    Location:172 → 478
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1 → 94
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  6. XM_024453493.1 → XP_024309261.1  metabotropic glutamate receptor 7 isoform X3

    Conserved Domains (3) summary
    pfam07562
    Location:104 → 152
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15451
    Location:172 → 478
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1 → 94
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  7. XM_024453497.1 → XP_024309265.1  metabotropic glutamate receptor 7 isoform X3

    Conserved Domains (3) summary
    pfam07562
    Location:104 → 152
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15451
    Location:172 → 478
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1 → 94
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  8. XM_024453498.1 → XP_024309266.1  metabotropic glutamate receptor 7 isoform X3

    Conserved Domains (3) summary
    pfam07562
    Location:104 → 152
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15451
    Location:172 → 478
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1 → 94
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RNA

  1. XR_001740136.2 RNA Sequence

  2. XR_001740137.2 RNA Sequence

  3. XR_001740134.2 RNA Sequence

  4. XR_001740135.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181875.1: Suppressed sequence

    Description
    NM_181875.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14831.1 GenPept UniProtKB/Swiss-Prot:Q14831

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