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GRM7 glutamate metabotropic receptor 7 [ Homo sapiens (human) ]

Gene ID: 2917, updated on 18-Sep-2018

Summary

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Official Symbol
GRM7provided by HGNC
Official Full Name
glutamate metabotropic receptor 7provided by HGNC
Primary source
HGNC:HGNC:4599
See related
Ensembl:ENSG00000196277 MIM:604101; Vega:OTTHUMG00000125549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUR7; MGLU7; GPRC1G; MGLUR7; PPP1R87
Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all

Genomic context

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See GRM7 in Genome Data Viewer
Location:
3p26.1
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (6861115..7743038)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (6902802..7783218)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene GRM7 antisense RNA 3 Neighboring gene uncharacterized LOC105376943 Neighboring gene uncharacterized LOC105376945 Neighboring gene GRM7 antisense RNA 2 Neighboring gene GRM7 antisense RNA 1 Neighboring gene uncharacterized LOC101927394 Neighboring gene LMCD1 antisense RNA 1 Neighboring gene uncharacterized LOC107986010 Neighboring gene RNA, U4atac small nuclear 17, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

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Related articles in PubMed

  1. Association study of GRM7 polymorphisms with major depressive disorder in the Chinese Han population. Niu W, et al. Psychiatr Genet, 2017 Apr. PMID 28027116
  2. Test for association of common variants in GRM7 with alcohol consumption. Melroy-Greif WE, et al. Alcohol, 2016 Sep. PMID 27788777, Free PMC Article
  3. Glutamate receptor, metabotropic 7 (GRM7) gene variations and susceptibility to autism: A case-control study. Noroozi R, et al. Autism Res, 2016 Nov. PMID 27312574
  4. The GRM7 gene, early response to risperidone, and schizophrenia: a genome-wide association study and a confirmatory pharmacogenetic analysis. Sacchetti E, et al. Pharmacogenomics J, 2017 Mar. PMID 26856250
  5. Association study of GRM7 polymorphisms and schizophrenia in the Chinese Han population. Niu W, et al. Neurosci Lett, 2015 Sep 14. PMID 26254163

See all (65) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. The results of this study indicate that the GRM7 rs9814881 might be associated with MDD in the Chinese Han population.
    Title: Association study of GRM7 polymorphisms with major depressive disorder in the Chinese Han population.
  2. study to evaluate evidence for association between GRM7 and alcohol behaviors using an SNP approach, as well as a gene-based approach in two independent samples; Rs3749380 was suggestively associated with alcohol consumption in one sample with the minor T allele conferring risk; there was no evidence for association in the other sample
    Title: Test for association of common variants in GRM7 with alcohol consumption.
  3. Autism spectrum disorder (ASD) as a synaptopathy is revealed to be pertained to aberrant glutamatergic neurotransmission. Glutamate receptor, metabotropic 7 (GRM7) is a receptor coding gene of this pathway.
    Title: Glutamate receptor, metabotropic 7 (GRM7) gene variations and susceptibility to autism: A case-control study.
  4. GRM7 rs2133450 may have translational relevance as a predictor of response to risperidone in schizophrenia.
    Title: The GRM7 gene, early response to risperidone, and schizophrenia: a genome-wide association study and a confirmatory pharmacogenetic analysis.
  5. Multiple genetic models identified 1 significant locus, GRM7, for 2 hypertension-derived traits.
    Title: Longitudinal analytical approaches to genetic data.
  6. Study represents a genetic association test towards single variant and multi-markers interaction of GRM7 and GRM8 genes in both schizophrenia and major depressive disorders in Han Chinese population
    Title: Significant association of GRM7 and GRM8 genes with schizophrenia and major depressive disorder in the Han Chinese population.
  7. Glutamate system genes have been associated with disease risk in recent analyses from the Psychiatric Genomics Consortium.
    Title: Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes.
  8. results indicate that the GRM7 SNPs rs13353402 and rs1531939 might be associated with schizophrenia in Chinese Han population.
    Title: Association study of GRM7 polymorphisms and schizophrenia in the Chinese Han population.
  9. results reported here do not support a role for GRM7 in ADHD
    Title: Lack of association between the GRM7 gene and attention deficit hyperactivity disorder.
  10. Copy number variants at GRM7 may have a role in the etiology of bipolar disorder.
    Title: Allelic association, DNA resequencing and copy number variation at the metabotropic glutamate receptor GRM7 gene locus in bipolar disorder.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
A genome-wide scan for breast cancer risk haplotypes among African American women.
NHGRI GWA Catalog
Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog
Genome-wide association study of panic disorder in the Japanese population.
NHGRI GWA Catalog
Genome-wide association study of personality traits in bipolar patients.
NHGRI GWA Catalog
Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
NHGRI GWA Catalog

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of GRM7 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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  • Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystem (from REACTOME)
    Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystemThe class C G-protein-coupled receptors are a class of G-protein coupled receptors that include the metabotropic glutamate receptors and several additional receptors (Brauner-Osborne H et al, 2007). ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class C Metabotropic glutamate, pheromone, organism-specific biosystem (from WikiPathways)
    GPCRs, Class C Metabotropic glutamate, pheromone, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Glutamatergic synapse, organism-specific biosystem (from KEGG)
    Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Glutamatergic synapse, conserved biosystem (from KEGG)
    Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
    Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
    Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ40498

Gene Ontology Provided by GOA

Function Evidence Code Pubs
adenylate cyclase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
glutamate receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
group III metabotropic glutamate receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
serine binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
  
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
NOT behavioral fear response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
negative regulation of glutamate secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
regulation of cyclase activity IEA
Inferred from Electronic Annotation
more info
  
regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
asymmetric synapse ISS
Inferred from Sequence or Structural Similarity
more info
  
axon ISS
Inferred from Sequence or Structural Similarity
more info
  
cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
dendritic shaft ISS
Inferred from Sequence or Structural Similarity
more info
  
integral component of membrane IDA
Inferred from Direct Assay
more info
 PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
plasma membrane TAS
Traceable Author Statement
more info
  
postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
presynaptic active zone ISS
Inferred from Sequence or Structural Similarity
more info
  
presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
metabotropic glutamate receptor 7
Names
glutamate receptor, metabotropic 7
protein phosphatase 1, regulatory subunit 87

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029781.1 RefSeqGene

    Range
    5001..885417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000844.3 → NP_000835.1  metabotropic glutamate receptor 7 isoform a precursor

    See identical proteins and their annotated locations for NP_000835.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as hmGluR7a) encodes the predominant isoform (a).
    Source sequence(s)
    AB209214, AK123326, AK312488, X94552
    Consensus CDS
    CCDS43042.1
    UniProtKB/Swiss-Prot
    Q14831
    UniProtKB/TrEMBL
    B2R693, Q59G95
    Related
    ENSP00000350348.4, OTTHUMP00000155219, ENST00000357716.8, OTTHUMT00000246895
    Conserved Domains (4) summary
    cd06376
    Location:47 → 511
    PBP1_mGluR_groupIII; Ligand-binding domain of the group III metabotropic glutamate receptor
    pfam00003
    Location:602 → 847
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:77 → 484
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:521 → 567
    NCD3G; Nine Cysteines Domain of family 3 GPCR

  2. NM_181874.2 → NP_870989.1  metabotropic glutamate receptor 7 isoform b precursor

    See identical proteins and their annotated locations for NP_870989.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as hmGluR7b) differs in the 3' UTR and includes an alternate segment in the 3' coding region, compared to variant 1, which results in a frameshift. The encoded isoform (b) has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK123326, AK312488, BC136459, X94552
    UniProtKB/Swiss-Prot
    Q14831
    UniProtKB/TrEMBL
    B2R693, B9EGG9
    Related
    ENSP00000417536.1, OTTHUMP00000214675, ENST00000486284.5, OTTHUMT00000354360
    Conserved Domains (4) summary
    cd06376
    Location:47 → 511
    PBP1_mGluR_groupIII; Ligand-binding domain of the group III metabotropic glutamate receptor
    pfam00003
    Location:602 → 847
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:77 → 484
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:521 → 567
    NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    6861115..7743038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006272.1 → XP_016861761.1  metabotropic glutamate receptor 7 isoform X1

    Related
    ENSP00000384585.4, ENST00000402647.6

  2. XM_017006273.1 → XP_016861762.1  metabotropic glutamate receptor 7 isoform X2

  3. XM_024453495.1 → XP_024309263.1  metabotropic glutamate receptor 7 isoform X3

    Conserved Domains (3) summary
    pfam07562
    Location:104 → 152
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15451
    Location:172 → 478
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1 → 94
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  4. XM_024453492.1 → XP_024309260.1  metabotropic glutamate receptor 7 isoform X3

    Conserved Domains (3) summary
    pfam07562
    Location:104 → 152
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15451
    Location:172 → 478
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1 → 94
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  5. XM_024453494.1 → XP_024309262.1  metabotropic glutamate receptor 7 isoform X3

    Conserved Domains (3) summary
    pfam07562
    Location:104 → 152
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15451
    Location:172 → 478
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1 → 94
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  6. XM_024453493.1 → XP_024309261.1  metabotropic glutamate receptor 7 isoform X3

    Conserved Domains (3) summary
    pfam07562
    Location:104 → 152
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15451
    Location:172 → 478
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1 → 94
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  7. XM_024453497.1 → XP_024309265.1  metabotropic glutamate receptor 7 isoform X3

    Conserved Domains (3) summary
    pfam07562
    Location:104 → 152
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15451
    Location:172 → 478
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1 → 94
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  8. XM_024453498.1 → XP_024309266.1  metabotropic glutamate receptor 7 isoform X3

    Conserved Domains (3) summary
    pfam07562
    Location:104 → 152
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15451
    Location:172 → 478
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1 → 94
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RNA

  1. XR_001740136.2 RNA Sequence

  2. XR_001740137.2 RNA Sequence

  3. XR_001740134.2 RNA Sequence

  4. XR_001740135.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181875.1: Suppressed sequence

    Description
    NM_181875.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14831.1 GenPept UniProtKB/Swiss-Prot:Q14831

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