U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hspa9 heat shock protein family A (Hsp70) member 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291671, updated on 22-May-2022

Summary

Symbol
Hspa9provided by RGD
Full Name
heat shock protein family A (Hsp70) member 9provided by RGD
Primary source
RGD:1311806
See related
Ensembl:ENSRNOG00000019525 AllianceGenome:RGD:1311806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Crp40; PBP74; GRP-75; Hspa9a
Summary
Enables chaperone binding activity; fibroblast growth factor binding activity; and heat shock protein binding activity. Involved in several processes, including cellular response to interleukin-1; response to folic acid; and response to thyroxine. Located in mitochondrion. Biomarker of Parkinsonism and brain ischemia. Human ortholog(s) of this gene implicated in Parkinson's disease and autosomal dominant sideroblastic anemia 4. Orthologous to human HSPA9 (heat shock protein family A (Hsp70) member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1892.8), Adrenal (RPKM 1730.9) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hspa9 in Genome Data Viewer
Location:
18p12
Exon count:
17
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (26536131..26554294, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (27731072..27749235, complement)

Chromosome 18 - NC_051353.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098162 Neighboring gene small nucleolar RNA SNORA26 Neighboring gene small nucleolar RNA SNORD63 Neighboring gene small nucleolar RNA SNORD63 Neighboring gene eukaryotic translation termination factor 1 Neighboring gene mucin-6-like Neighboring gene uncharacterized LOC108353164 Neighboring gene catenin alpha 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in iron-sulfur cluster assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in iron-sulfur cluster assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of hematopoietic stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of hematopoietic stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hematopoietic stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein export from nucleus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to folic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to thyroxine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial nucleoid IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
stress-70 protein, mitochondrial
Names
75 kDa glucose-regulated protein
GRP 75
catecholamine regulated protein 40
heat shock 70 kDa protein 9
heat shock 70kDa protein 9A
heat shock protein 9
heat shock protein family A member 9
heat shock protein, A
mortalin
mtHSP70
peptide-binding protein 74
stress-70 protein, mitochondrial-like

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100658.2NP_001094128.2  stress-70 protein, mitochondrial

    See identical proteins and their annotated locations for NP_001094128.2

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000299
    UniProtKB/TrEMBL
    F1M953
    Related
    ENSRNOP00000026696.4, ENSRNOT00000026696.7
    Conserved Domains (2) summary
    cd11733
    Location:52428
    HSPA9-like_NBD; Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins
    PRK00290
    Location:52656
    dnaK; molecular chaperone DnaK; Provisional

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051353.1 Reference mRatBN7.2 Primary Assembly

    Range
    26536131..26554294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)