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Jag1 jagged 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29146, updated on 7-May-2017
Official Symbol
Jag1provided by RGD
Official Full Name
jagged 1provided by RGD
Primary source
RGD:2937
See related
Ensembl:ENSRNOG00000007443
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
ligand responsible for activating Notch1 [RGD, Feb 2006]
Orthologs
Location:
3q36
Exon count:
26
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (130079361..130114781, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (136558688..136594108, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene McKusick-Kaufman syndrome Neighboring gene SLX4 interacting protein Neighboring gene uncharacterized LOC108350474 Neighboring gene uncharacterized LOC102547655 Neighboring gene uncharacterized LOC103691902

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Apelin signaling pathway, organism-specific biosystem (from KEGG)
    Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
  • Breast cancer, organism-specific biosystem (from KEGG)
    Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Breast cancer, conserved biosystem (from KEGG)
    Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
  • Endocrine resistance, organism-specific biosystem (from KEGG)
    Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • Endocrine resistance, conserved biosystem (from KEGG)
    Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Notch Signaling Pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
  • Notch signaling pathway, organism-specific biosystem (from KEGG)
    Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
  • Notch signaling pathway, conserved biosystem (from KEGG)
    Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by NOTCH3, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH3, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by NOTCH4, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Th1 and Th2 cell differentiation, organism-specific biosystem (from KEGG)
    Th1 and Th2 cell differentiation, organism-specific biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
  • Th1 and Th2 cell differentiation, conserved biosystem (from KEGG)
    Th1 and Th2 cell differentiation, conserved biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
Notch binding IEA
Inferred from Electronic Annotation
more info
 
Notch binding ISO
Inferred from Sequence Orthology
more info
 
Notch binding TAS
Traceable Author Statement
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Notch signaling involved in heart development IEA
Inferred from Electronic Annotation
more info
 
Notch signaling involved in heart development ISO
Inferred from Sequence Orthology
more info
 
Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
T cell mediated immunity IEA
Inferred from Electronic Annotation
more info
 
T cell mediated immunity ISO
Inferred from Sequence Orthology
more info
 
animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
animal organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
aorta morphogenesis IEA
Inferred from Electronic Annotation
more info
 
aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
 
auditory receptor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
auditory receptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
auditory receptor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
camera-type eye development ISO
Inferred from Sequence Orthology
more info
 
cardiac neural crest cell development involved in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cardiac neural crest cell development involved in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cardiac right ventricle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cardiac right ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cardiac septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cardiac septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell fate determination NAS
Non-traceable Author Statement
more info
PubMed 
ciliary body morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ciliary body morphogenesis ISO
Inferred from Sequence Orthology
more info
 
distal tubule development IEA
Inferred from Electronic Annotation
more info
 
distal tubule development ISO
Inferred from Sequence Orthology
more info
 
endocardial cushion cell development IEA
Inferred from Electronic Annotation
more info
 
endocardial cushion cell development ISO
Inferred from Sequence Orthology
more info
 
glomerular visceral epithelial cell development IEA
Inferred from Electronic Annotation
more info
 
glomerular visceral epithelial cell development ISO
Inferred from Sequence Orthology
more info
 
glomerular visceral epithelial cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
inner ear development ISO
Inferred from Sequence Orthology
more info
 
loop of Henle development IEA
Inferred from Electronic Annotation
more info
 
loop of Henle development ISO
Inferred from Sequence Orthology
more info
 
morphogenesis of an epithelial sheet IEA
Inferred from Electronic Annotation
more info
 
morphogenesis of an epithelial sheet ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
nephron development ISO
Inferred from Sequence Orthology
more info
 
nephron development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
neuronal stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of myeloid cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
pulmonary artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
pulmonary artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
pulmonary valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
pulmonary valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
response to muramyl dipeptide IEA
Inferred from Electronic Annotation
more info
 
response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
adherens junction IEA
Inferred from Electronic Annotation
more info
 
adherens junction ISO
Inferred from Sequence Orthology
more info
 
adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
 
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019147.1NP_062020.1  protein jagged-1 precursor

    See identical proteins and their annotated locations for NP_062020.1

    Status: PROVISIONAL

    Source sequence(s)
    L38483
    UniProtKB/Swiss-Prot
    Q63722
    Related
    ENSRNOP00000010638.5, ENSRNOT00000010638.7
    Conserved Domains (5) summary
    smart00215
    Location:863930
    VWC_out; von Willebrand factor (vWF) type C domain
    cd00054
    Location:629665
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:748777
    EGF; EGF-like domain
    pfam01414
    Location:167229
    DSL; Delta serrate ligand
    pfam07657
    Location:32106
    MNNL; N terminus of Notch ligand

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    130079361..130114781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    123126087..123161497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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