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Lipg lipase G, endothelial type [ Rattus norvegicus (Norway rat) ]

Gene ID: 291437, updated on 17-Aug-2024

Summary

Official Symbol
Lipgprovided by RGD
Official Full Name
lipase G, endothelial typeprovided by RGD
Primary source
RGD:1310740
See related
EnsemblRapid:ENSRNOG00000018694 AllianceGenome:RGD:1310740
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
lipase
Summary
Predicted to enable lipoprotein lipase activity and phospholipase A1 activity. Involved in cell population proliferation and response to nutrient. Located in extracellular space. Used to study hypertension. Human ortholog(s) of this gene implicated in cardiovascular system disease; cerebral infarction; coronary artery disease; and myocardial infarction. Orthologous to human LIPG (lipase G, endothelial type). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 40.1), Testes (RPKM 38.7) and 6 other tissues See more
Orthologs
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Genomic context

Location:
18q12.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (70790077..70811259, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (68514923..68536105, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (70903528..70924434, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene acetyl-CoA acyltransferase 2 Neighboring gene uncharacterized LOC102552571 Neighboring gene uncharacterized LOC102557471 Neighboring gene transfer RNA proline (anticodon AGG) 92 Neighboring gene solute carrier family 25 member 5, pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables lipoprotein lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A1 activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phospholipase A1 activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase A1 activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phospholipase activity ISO
Inferred from Sequence Orthology
more info
 
enables triglyceride lipase activity ISO
Inferred from Sequence Orthology
more info
 
enables triglyceride lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in high-density lipoprotein particle remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in high-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of high-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of lipoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in reverse cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
endothelial lipase
Names
EDL
endothelial-derived lipase
lipase, endothelial
phospholipase A1
NP_001012759.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012741.2NP_001012759.1  endothelial lipase precursor

    See identical proteins and their annotated locations for NP_001012759.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q5D216, Q8VBX1
    UniProtKB/TrEMBL
    A6KRH1
    Related
    ENSRNOP00000025257.5, ENSRNOT00000025257.8
    Conserved Domains (3) summary
    TIGR03230
    Location:53488
    lipo_lipase; lipoprotein lipase
    cd00707
    Location:51342
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01758
    Location:349485
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    70790077..70811259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)