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Spag6 sperm associated antigen 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291340, updated on 19-Nov-2025
Official Symbol
Spag6provided by RGD
Official Full Name
sperm associated antigen 6provided by RGD
Primary source
RGD:1305616
See related
Ensembl:ENSRNOG00000022021 AllianceGenome:RGD:1305616
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Spag6l
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in epithelial cilium movement involved in extracellular fluid movement and plasma membrane bounded cell projection organization. Predicted to be located in extracellular region. Predicted to be active in acrosomal vesicle; cytoskeleton; and sperm principal piece. Orthologous to human SPAG6 (sperm associated antigen 6). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Testes (RPKM 31.9), Adrenal (RPKM 5.5) and 8 other tissues See more
Orthologs
human mouse all
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See Spag6 in Genome Data Viewer
Location:
17q12.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (86258418..86309922)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (81352372..81401504)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (85382314..85437976)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene COMM domain containing 3 Neighboring gene BMI1 proto-oncogene, polycomb ring finger Neighboring gene uncharacterized LOC120097847 Neighboring gene phosphatidylinositol-5-phosphate 4-kinase type 2 alpha

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. cDNA cloning and characterization of a human sperm antigen (SPAG6) with homology to the product of the Chlamydomonas PF16 locus. Neilson LI, et al. Genomics, 1999 Sep 15. PMID 10493827
  2. Whole-exome sequencing identifies mutations in FSIP2 as a recurrent cause of multiple morphological abnormalities of the sperm flagella. Martinez G, et al. Hum Reprod, 2018 Oct 1. PMID 30137358
  3. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cilium movement involved in extracellular fluid movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection extension IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme IEA
Inferred from Electronic Annotation
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm principal piece IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm principal piece IEA
Inferred from Electronic Annotation
more info
  
located_in sperm principal piece ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
sperm-associated antigen 6

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106125.1 → NP_001099595.1  sperm-associated antigen 6

    See identical proteins and their annotated locations for NP_001099595.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473990
    UniProtKB/TrEMBL
    A6JM96, A6JSP6, G3V682
    Related
    ENSRNOP00000002513.7, ENSRNOT00000002513.9
    Conserved Domains (3) summary
    COG5064
    Location:112 → 423
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00044
    Location:378 → 406
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:162 → 194
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    86258418..86309922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095562.2 → XP_038951490.1  sperm-associated antigen 6 isoform X1

    UniProtKB/TrEMBL
    A6JM96, A6JSP6, G3V682
    Conserved Domains (3) summary
    COG5064
    Location:112 → 423
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00044
    Location:378 → 406
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:162 → 194
    ARM; armadillo repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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