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GRM3 glutamate metabotropic receptor 3 [ Homo sapiens (human) ]

Gene ID: 2913, updated on 23-Nov-2021

Summary

Official Symbol
GRM3provided by HGNC
Official Full Name
glutamate metabotropic receptor 3provided by HGNC
Primary source
HGNC:HGNC:4595
See related
Ensembl:ENSG00000198822 MIM:601115
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUR3; mGlu3; GPRC1C; MGLUR3
Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 15.9) See more
Orthologs
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Genomic context

See GRM3 in Genome Data Viewer
Location:
7q21.11-q21.12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (86643909..86864879)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (86273225..86494195)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 972 Neighboring gene suppressor of cytokine signaling 5 pseudogene 1 Neighboring gene uncharacterized LOC105375382 Neighboring gene uncharacterized LOC107986814 Neighboring gene GRM3 antisense RNA 1 Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator family member 2 Neighboring gene uncharacterized LOC112268008 Neighboring gene DMTF1 antisense RNA 1 Neighboring gene cyclin D binding myb like transcription factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.
GeneReviews: Not available
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of GRM3 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables glutamate receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables group II metabotropic glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables scaffold protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in astrocyte projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
metabotropic glutamate receptor 3
Names
glutamate receptor, metabotropic 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000840.3NP_000831.2  metabotropic glutamate receptor 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000831.2

    Status: REVIEWED

    Source sequence(s)
    AC002081, AC004829, BC041407, X77748
    Consensus CDS
    CCDS5600.1
    UniProtKB/Swiss-Prot
    Q14832
    UniProtKB/TrEMBL
    A4D1D0
    Related
    ENSP00000355316.2, ENST00000361669.7
    Conserved Domains (4) summary
    cd06375
    Location:37494
    PBP1_mGluR_groupII; Ligand binding domain of the group II metabotropic glutamate receptor
    pfam00003
    Location:588825
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:67469
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:506554
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  2. NM_001363522.2NP_001350451.1  metabotropic glutamate receptor 3 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC002081, BC041407, DC374499, DQ315361
    Consensus CDS
    CCDS87515.1
    Related
    ENSP00000398767.1, ENST00000439827.1
    Conserved Domains (1) summary
    cd06375
    Location:33441
    PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    86643909..86864879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012073.2XP_016867562.1  metabotropic glutamate receptor 3 isoform X2

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