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PRSS50 serine protease 50 [ Homo sapiens (human) ]

Gene ID: 29122, updated on 17-Oct-2021

Summary

Official Symbol
PRSS50provided by HGNC
Official Full Name
serine protease 50provided by HGNC
Primary source
HGNC:HGNC:17910
See related
Ensembl:ENSG00000283706 MIM:607950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT20; TSP50
Expression
Biased expression in testis (RPKM 18.5) and thyroid (RPKM 1.9) See more
Orthologs
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Genomic context

See PRSS50 in Genome Data Viewer
Location:
3p21.31
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (46712117..46717869, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (46753607..46759359, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ALS2 C-terminal like Neighboring gene transmembrane inner ear Neighboring gene serine protease 46, pseudogene Neighboring gene serine protease 45, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables threonine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables threonine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
probable threonine protease PRSS50
Names
cancer/testis antigen 20
protease, serine 50
testes-specific protease 50
testicular tissue protein Li 210
testis-specific protease-like protein 50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013270.5NP_037402.1  probable threonine protease PRSS50 precursor

    See identical proteins and their annotated locations for NP_037402.1

    Status: VALIDATED

    Source sequence(s)
    AF100707, BC033016, BC037775
    Consensus CDS
    CCDS2745.1
    UniProtKB/Swiss-Prot
    Q9UI38
    UniProtKB/TrEMBL
    A0A140VJY3
    Related
    ENSP00000326598.7, ENST00000315170.13
    Conserved Domains (1) summary
    cd00190
    Location:118353
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    46712117..46717869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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