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BRD7 bromodomain containing 7 [ Homo sapiens (human) ]

Gene ID: 29117, updated on 22-Aug-2020

Summary

Official Symbol
BRD7provided by HGNC
Official Full Name
bromodomain containing 7provided by HGNC
Primary source
HGNC:HGNC:14310
See related
Ensembl:ENSG00000166164 MIM:618489
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BP75; NAG4; CELTIX1
Summary
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in testis (RPKM 21.8), spleen (RPKM 16.7) and 25 other tissues See more
Orthologs

Genomic context

See BRD7 in Genome Data Viewer
Location:
16q12.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (50315957..50368988, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (50352929..50402845, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene terminal nucleotidyltransferase 4B Neighboring gene adenylate cyclase 7 Neighboring gene microRNA 6771 Neighboring gene Sharpr-MPRA regulatory region 13482 Neighboring gene long intergenic non-protein coding RNA 2178

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of liver enzymes in korean children.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
lysine-acetylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
bromodomain-containing protein 7
Names
75 kDa bromodomain protein
protein CELTIX-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023418.1 RefSeqGene

    Range
    5001..54917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001173984.3NP_001167455.1  bromodomain-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001167455.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007493, AC007597, AF152604, AF213969, AW615116
    Consensus CDS
    CCDS54007.1
    UniProtKB/Swiss-Prot
    Q9NPI1
    Related
    ENSP00000378181.2, ENST00000394689.2
    Conserved Domains (2) summary
    cd05513
    Location:135232
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:287533
    DUF3512; Domain of unknown function (DUF3512)
  2. NM_013263.5NP_037395.2  bromodomain-containing protein 7 isoform 2

    See identical proteins and their annotated locations for NP_037395.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks one internal residue, compared to isoform 1.
    Source sequence(s)
    AC007493, AC007597, AF152604, AW615116, DA645362
    Consensus CDS
    CCDS10742.1
    UniProtKB/Swiss-Prot
    Q9NPI1
    Related
    ENSP00000378180.3, ENST00000394688.7
    Conserved Domains (2) summary
    cd05513
    Location:135232
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:287532
    DUF3512; Domain of unknown function (DUF3512)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    50315957..50368988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523046.3XP_011521348.1  bromodomain-containing protein 7 isoform X1

    Conserved Domains (2) summary
    cd05513
    Location:152249
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:304550
    DUF3512; Domain of unknown function (DUF3512)
  2. XM_011523047.2XP_011521349.1  bromodomain-containing protein 7 isoform X2

    Conserved Domains (2) summary
    cd05513
    Location:152249
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:304549
    DUF3512; Domain of unknown function (DUF3512)
  3. XM_017023181.1XP_016878670.1  bromodomain-containing protein 7 isoform X8

  4. XM_011523048.2XP_011521350.1  bromodomain-containing protein 7 isoform X3

    Conserved Domains (2) summary
    cd05513
    Location:152249
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:304514
    DUF3512; Domain of unknown function (DUF3512)
  5. XM_011523050.3XP_011521352.1  bromodomain-containing protein 7 isoform X7

    Conserved Domains (2) summary
    pfam12024
    Location:85331
    DUF3512; Domain of unknown function (DUF3512)
    cl02556
    Location:130
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
  6. XM_011523049.2XP_011521351.1  bromodomain-containing protein 7 isoform X4

    Conserved Domains (2) summary
    cd05513
    Location:152249
    Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
    pfam12024
    Location:304513
    DUF3512; Domain of unknown function (DUF3512)
  7. XM_017023180.1XP_016878669.1  bromodomain-containing protein 7 isoform X6

  8. XM_017023179.1XP_016878668.1  bromodomain-containing protein 7 isoform X5

RNA

  1. XR_933291.3 RNA Sequence

  2. XR_933289.3 RNA Sequence

  3. XR_001751896.2 RNA Sequence

  4. XR_933290.3 RNA Sequence

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