Format

Send to:

Choose Destination

TAGLN3 transgelin 3 [ Homo sapiens (human) ]

Gene ID: 29114, updated on 10-Oct-2020

Summary

Official Symbol
TAGLN3provided by HGNC
Official Full Name
transgelin 3provided by HGNC
Primary source
HGNC:HGNC:29868
See related
Ensembl:ENSG00000144834 MIM:607953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NP22; NP24; NP25
Expression
Restricted expression toward brain (RPKM 97.4) See more
Orthologs

Genomic context

See TAGLN3 in Genome Data Viewer
Location:
3q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (111998922..112013885)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (111717586..111732735)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol specific phospholipase C X domain containing 2 Neighboring gene pleckstrin homology like domain family B member 2 Neighboring gene uncharacterized LOC105374040 Neighboring gene abhydrolase domain containing 10, depalmitoylase Neighboring gene transmembrane serine protease 7 Neighboring gene riboflavin kinase pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
central nervous system development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transgelin-3
Names
neuronal protein 22
neuronal protein NP25

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008272.2NP_001008273.1  transgelin-3

    See identical proteins and their annotated locations for NP_001008273.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC015329, BI752099, BM894229
    Consensus CDS
    CCDS33816.1
    UniProtKB/Swiss-Prot
    Q9UI15
    Related
    ENSP00000419105.1, ENST00000478951.6
    Conserved Domains (2) summary
    cd00014
    Location:25133
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00402
    Location:174197
    Calponin; Calponin family repeat
  2. NM_001008273.2NP_001008274.1  transgelin-3

    See identical proteins and their annotated locations for NP_001008274.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BG912462, BI822856, BM894229, CK003985
    Consensus CDS
    CCDS33816.1
    UniProtKB/Swiss-Prot
    Q9UI15
    Related
    ENSP00000391160.2, ENST00000455401.6
    Conserved Domains (2) summary
    cd00014
    Location:25133
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00402
    Location:174197
    Calponin; Calponin family repeat
  3. NM_013259.3NP_037391.2  transgelin-3

    See identical proteins and their annotated locations for NP_037391.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AF112201, BI919263, BM894229, BQ640029
    Consensus CDS
    CCDS33816.1
    UniProtKB/Swiss-Prot
    Q9UI15
    Related
    ENSP00000377494.2, ENST00000393917.6
    Conserved Domains (2) summary
    cd00014
    Location:25133
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00402
    Location:174197
    Calponin; Calponin family repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    111998922..112013885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center