Irf4 interferon regulatory factor 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Irf4provided by RGD
Official Full Name: interferon regulatory factor 4provided by RGD
Primary source: RGD:1308050
See related: Ensembl:ENSRNOG00000061070 AllianceGenome:RGD:1308050
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including T-helper 17 cell lineage commitment; defense response to protozoan; and positive regulation of macromolecule biosynthetic process. Predicted to act upstream of or within several processes, including myeloid dendritic cell differentiation; negative regulation of toll-like receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of nucleosome. Predicted to be active in nucleus. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and pigmentation disease. Orthologous to human IRF4 (interferon regulatory factor 4). [provided by Alliance of Genome Resources, Jun 2025]
Expression: Biased expression in Spleen (RPKM 119.3), Thymus (RPKM 49.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (33930460..33948842, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (33721800..33742570, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (34886746..34905191, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of interferon regulatory factor 4 and inflammation in secondary injury of intracerebral haemorrhage.
Title: Expression of interferon regulatory factor 4 and inflammation in secondary injury of intracerebral haemorrhage.
Functional analysis of the Mum1 ortholog in mouse and human malignant B cells.
Title: Multiple myeloma oncogene 1 (MUM1)/interferon regulatory factor 4 (IRF4) upregulates monokine induced by interferon-gamma (MIG) gene expression in B-cell malignancy.
IRF4 protects arteries against neointima formation by promoting the expression of KLF4 by directly binding to its promoter.
Title: Interferon Regulatory Factor 4 Inhibits Neointima Formation by Engaging Krüppel-Like Factor 4 Signaling.
both IRF3 and IRF4 are induced by adiponectin, with adiponectin-AMPK and adiponectin-PPARalpha signalling regulating IRF3 and IRF4, respectively.
Title: A key role for interferon regulatory factors in mediating early-life metabolic defects in male offspring of maternal protein restricted rats.

Submit: New GeneRIF Correction

General gene information

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Markers

Irf4 (e-PCR), detects polymorphism
- UniSTS:536527

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T-helper 17 cell lineage commitment	IEA Inferred from Electronic Annotation more info
involved_in T-helper 17 cell lineage commitment	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in defense response to protozoan	IEA Inferred from Electronic Annotation more info
involved_in defense response to protozoan	ISO Inferred from Sequence Orthology more info
involved_in dendritic cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in immune system process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lymphocyte activation involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in lymphocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myeloid dendritic cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myeloid dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in myeloid dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-13 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organismal process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon regulatory factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106108.2 → NP_001099578.1 interferon regulatory factor 4

See identical proteins and their annotated locations for NP_001099578.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A0G2JXN7, A6J7L4, D3ZEX6

Related

ENSRNOP00000074106.1, ENSRNOT00000088931.3

Conserved Domains (2) summary

pfam00605
Location:23 → 128

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:250 → 418

IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

33930460..33948842 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006253899.5 → XP_006253961.1 interferon regulatory factor 4 isoform X1

UniProtKB/TrEMBL

A0A0G2JXN7

Conserved Domains (2) summary

pfam00605
Location:23 → 128

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:249 → 417

IRF-3; Interferon-regulatory factor 3
XM_006253900.5 → XP_006253962.1 interferon regulatory factor 4 isoform X2

UniProtKB/TrEMBL

A0A8I6A257

Related

ENSRNOP00000086418.2, ENSRNOT00000098421.2

Conserved Domains (2) summary

pfam00605
Location:23 → 128

IRF; Interferon regulatory factor transcription factor

pfam10401
Location:214 → 382

IRF-3; Interferon-regulatory factor 3