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GRM1 glutamate metabotropic receptor 1 [ Homo sapiens (human) ]

Gene ID: 2911, updated on 17-Jun-2024

Summary

Official Symbol
GRM1provided by HGNC
Official Full Name
glutamate metabotropic receptor 1provided by HGNC
Primary source
HGNC:HGNC:4593
See related
Ensembl:ENSG00000152822 MIM:604473; AllianceGenome:HGNC:4593
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MGLU1; SCA44; GPRC1A; MGLUR1; SCAR13; PPP1R85
Summary
This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Expression
Biased expression in brain (RPKM 2.8), heart (RPKM 1.1) and 2 other tissues See more
Orthologs
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Genomic context

See GRM1 in Genome Data Viewer
Location:
6q24.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (146027707..146437601)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (147215189..147630683)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (146348843..146758737)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene EPM2A divergent transcript Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:146135340-146135894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25227 Neighboring gene F-box protein 30 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25228 Neighboring gene uncharacterized LOC124901420 Neighboring gene SNF2 histone linker PHD RING helicase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25229 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:146285382-146286369 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:146350016-146350516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:146350517-146351017 Neighboring gene FUN14 domain containing 2 pseudogene 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:146578666-146579217 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:146678820-146680019 Neighboring gene RNA, 5S ribosomal pseudogene 222 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:146709629-146710828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17644 Neighboring gene Sharpr-MPRA regulatory region 4102 Neighboring gene RAB32, member RAS oncogene family Neighboring gene ADGB divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates N-methyl-D-aspartate receptor function by activating metabotropic glutamate receptor 1 in human brain noradrenergic neurons PubMed
tat HIV-1 Tat potentiates the depolarization-evoked exocytosis of aspartate from human neocortical terminals, which involves the metabotropic glutamate (mGlu) 1 receptor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in L-glutamate import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of G protein-coupled receptor dimeric complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of G protein-coupled receptor homodimeric complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
metabotropic glutamate receptor 1
Names
glutamate receptor, metabotropic 1
protein phosphatase 1, regulatory subunit 85

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012839.2 RefSeqGene

    Range
    6417..414956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001278064.2NP_001264993.1  metabotropic glutamate receptor 1 isoform alpha precursor

    See identical proteins and their annotated locations for NP_001264993.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (alpha).
    Source sequence(s)
    AB208837, AL035698, AL096867, BC136280, L76627, L76631
    Consensus CDS
    CCDS5209.1
    UniProtKB/Swiss-Prot
    B9EG79, F8W805, Q13255, Q13256, Q14757, Q14758, Q5VTF7, Q5VTF8, Q9NU10, Q9UGS9, Q9UGT0
    Related
    ENSP00000282753.1, ENST00000282753.6
    Conserved Domains (4) summary
    cd15449
    Location:591840
    7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:36510
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:521571
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11451194
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  2. NM_001278065.2NP_001264994.1  metabotropic glutamate receptor 1 isoform beta precursor

    See identical proteins and their annotated locations for NP_001264994.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 3' coding region, compared to variant 3. The encoded isoform (beta) is shorter and contains a distinct C-terminus, compared to isoform alpha. Isoform beta has a different subcellular distribution than isoform alpha and may be functionally distinct due to differential G-protein coupling of its novel C-terminal sequence (PMID: 9076744). Variants 4 and 5 encode the same isoform.
    Source sequence(s)
    AB208837, AL035698, AL096867, L76627, L76631
    Consensus CDS
    CCDS47497.1
    UniProtKB/TrEMBL
    Q59HC2
    Related
    ENSP00000424095.1, ENST00000492807.6
    Conserved Domains (3) summary
    cd15449
    Location:591840
    7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:36510
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:521571
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  3. NM_001278066.1NP_001264995.1  metabotropic glutamate receptor 1 isoform beta precursor

    See identical proteins and their annotated locations for NP_001264995.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate internal exon in the 3' coding region and uses an alternate splice site in the 3'-terminal exon, compared to variant 3. The encoded isoform (beta) is shorter and contains a distinct C-terminus, compared to isoform alpha. Isoform beta has a different subcellular distribution than isoform alpha and may be functionally distinct due to differential G-protein coupling of its novel C-terminal sequence (PMID: 9076744). Variants 4 and 5 encode the same isoform.
    Source sequence(s)
    AB208837, BC143777, L76627, L76631
    Consensus CDS
    CCDS47497.1
    UniProtKB/TrEMBL
    Q59HC2
    Related
    ENSP00000425599.1, ENST00000507907.1
    Conserved Domains (3) summary
    cd15449
    Location:591840
    7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:36510
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:521571
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  4. NM_001278067.1NP_001264996.1  metabotropic glutamate receptor 1 isoform d precursor

    See identical proteins and their annotated locations for NP_001264996.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 3. The encoded isoform (d) is shorter and contains a distinct C-terminus, compared to isoform alpha. Isoform d may have a distinct function compared to isoform alpha (PMID: 9776379).
    Source sequence(s)
    AB208837, BC143779, L76627, L76631
    Consensus CDS
    CCDS64548.1
    UniProtKB/TrEMBL
    Q59HC2
    Related
    ENSP00000347437.4, ENST00000355289.8
    Conserved Domains (3) summary
    cd15449
    Location:591840
    7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:36510
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:521571
    NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    146027707..146437601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010784.2XP_016866273.1  metabotropic glutamate receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    B9EG79, F8W805, Q13255, Q13256, Q14757, Q14758, Q5VTF7, Q5VTF8, Q9NU10, Q9UGS9, Q9UGT0
    Related
    ENSP00000354896.2, ENST00000361719.6
    Conserved Domains (4) summary
    cd15449
    Location:591840
    7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:36510
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:521571
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11451194
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  2. XM_011535782.2XP_011534084.1  metabotropic glutamate receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011534084.1

    UniProtKB/Swiss-Prot
    B9EG79, F8W805, Q13255, Q13256, Q14757, Q14758, Q5VTF7, Q5VTF8, Q9NU10, Q9UGS9, Q9UGT0
    Related
    ENSP00000516579.1, ENST00000706833.1
    Conserved Domains (4) summary
    cd15449
    Location:591840
    7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:36510
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:521571
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11451194
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  3. XM_017010783.2XP_016866272.1  metabotropic glutamate receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    B9EG79, F8W805, Q13255, Q13256, Q14757, Q14758, Q5VTF7, Q5VTF8, Q9NU10, Q9UGS9, Q9UGT0
    Related
    ENSP00000516581.1, ENST00000706835.1
    Conserved Domains (4) summary
    cd15449
    Location:591840
    7tmC_mGluR1; metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06374
    Location:36510
    PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
    pfam07562
    Location:521571
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    pfam10606
    Location:11451194
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
  4. XM_017010788.2XP_016866277.1  metabotropic glutamate receptor 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    147215189..147630683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355250.1XP_054211225.1  metabotropic glutamate receptor 1 isoform X1

  2. XM_054355248.1XP_054211223.1  metabotropic glutamate receptor 1 isoform X1

  3. XM_054355249.1XP_054211224.1  metabotropic glutamate receptor 1 isoform X1

  4. XM_054355251.1XP_054211226.1  metabotropic glutamate receptor 1 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_000838.3: Suppressed sequence

    Description
    NM_000838.3: This RefSeq was based on transcripts that have no full-length support, compared to the NM_001278064.1, which is also valid for CCDS5209.1. Therefore, NM_001114329.1 is suppressed, but the CCDS ID is retained for the other variant.
  2. NM_001114329.1: Suppressed sequence

    Description
    NM_001114329.1: This RefSeq was based on transcripts that have no full-length support, compared to NM_001278065.1, which is also valid for CCDS47497.1. Therefore, NM_001114329.1 is suppressed, but the CCDS ID is retained for the other variant.