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Eci2 enoyl-CoA delta isomerase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291075, updated on 8-Dec-2022

Summary

Official Symbol
Eci2provided by RGD
Official Full Name
enoyl-CoA delta isomerase 2provided by RGD
Primary source
RGD:1359427
See related
Ensembl:ENSRNOG00000066714 AllianceGenome:RGD:1359427
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Peci
Summary
Enables dodecenoyl-CoA delta-isomerase activity. Involved in fatty acid beta-oxidation. Located in mitochondrion and peroxisome. Orthologous to human ECI2 (enoyl-CoA delta isomerase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 875.7), Heart (RPKM 764.7) and 9 other tissues See more
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Genomic context

See Eci2 in Genome Data Viewer
Location:
17p12
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (29850884..29886781)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (30556926..30573324)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene endoplasmic reticulum protein 29, pseudogene 1 Neighboring gene testis expressed 56 Neighboring gene enoyl-Coenzyme A delta isomerase 3 Neighboring gene family with sequence similarity 217, member A

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC94706

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables delta(3)-delta(2)-enoyl-CoA isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables delta(3)-delta(2)-enoyl-CoA isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables fatty-acyl-CoA binding IEA
Inferred from Electronic Annotation
more info
 
enables intramolecular oxidoreductase activity, transposing C=C bonds IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisomal matrix IEA
Inferred from Electronic Annotation
more info
 
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
enoyl-CoA delta isomerase 2
Names
D3,D2-enoyl-CoA isomerase
delta(3),delta(2)-enoyl-CoA isomerase
dodecenoyl-CoA isomerase
enoyl-CoA delta isomerase 2, mitochondrial
enoyl-Coenzyme A delta isomerase 2
peroxisomal 3,2-trans-enoyl-CoA isomerase
peroxisomal D3,D2-enoyl-CoA isomerase
peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase
NP_001006967.1
XP_038951409.1
XP_038951410.1
XP_038951411.1
XP_038951412.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006966.1NP_001006967.1  enoyl-CoA delta isomerase 2 precursor

    See identical proteins and their annotated locations for NP_001006967.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083764
    UniProtKB/Swiss-Prot
    Q5XIC0
    Conserved Domains (2) summary
    pfam00887
    Location:38113
    ACBP; Acyl CoA binding protein
    cl23717
    Location:134389
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    29850884..29886781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095482.1XP_038951410.1  enoyl-CoA delta isomerase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QBE2
    Conserved Domains (2) summary
    pfam00887
    Location:580
    ACBP; Acyl CoA binding protein
    cl23717
    Location:101356
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
  2. XM_039095484.1XP_038951412.1  enoyl-CoA delta isomerase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QBE2
    Conserved Domains (2) summary
    pfam00887
    Location:580
    ACBP; Acyl CoA binding protein
    cl23717
    Location:101356
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
  3. XM_039095483.1XP_038951411.1  enoyl-CoA delta isomerase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QBE2
    Conserved Domains (2) summary
    pfam00887
    Location:580
    ACBP; Acyl CoA binding protein
    cl23717
    Location:101356
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
  4. XM_039095481.1XP_038951409.1  enoyl-CoA delta isomerase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QBE2
    Related
    ENSRNOP00000022022.4, ENSRNOT00000022022.7
    Conserved Domains (2) summary
    pfam00887
    Location:580
    ACBP; Acyl CoA binding protein
    cl23717
    Location:101356
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...